A whole head MEG study of the amplitude-modulation-following response: phase coherence, group delay and dipole source analysis

Schoonhoven, Ruurd; Boden, Catherine; Verbunt, J.P.A.; Munck, Jan C. de

doi:10.1016/s1388-2457(03)00200-1

Cited by 59 publications

(46 citation statements)

References 42 publications

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“…The SSR is tightly locked to the stimulus envelope and continues for the whole duration of the stimulus. Intracranial recordings from patients with epilepsy indicate that the response is generated in medial Heschl's gyrus (Bidet-Caulet et al, 2007;Brugge et al, 2009), which is consistent with several source analysis studies of the response (Gutschalk et al, 1999;Herdman et al, 2003;Pantev et al, 1996;Schoonhoven et al, 2003). It has therefore been suggested, that the response is primarily generated in the auditory core area and in particular in the more medial field that would correspond to A1 in primate auditory cortex (Hackett et al, 2001).…”

Section: Introductionsupporting

confidence: 81%

“…The BOLD activity shows two characteristics that were predicted based on the 40-Hz SSR (Galambos et al, 1981;Gutschalk et al, 1999;Hari et al, 1989;Herdman et al, 2003;Pantev et al, 1996;Schoonhoven et al, 2003): first, the activity detected by the AMversus pure-tone contrast (based on a boxcar regressor) is confined to the medial part of Heschl's gyrus. Second, the activity is sustained throughout the whole 32-s long stimuli.…”

Section: Discussionmentioning

confidence: 89%

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Potential fMRI correlates of 40-Hz phase locking in primary auditory cortex, thalamus and midbrain

Steinmann

Gutschalk

2011

NeuroImage

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Section: Introductionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 89%

Potential fMRI correlates of 40-Hz phase locking in primary auditory cortex, thalamus and midbrain

Steinmann

Gutschalk

2011

NeuroImage

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“…One example illustrated above arises in the search for SSR sources as a function of modulation frequency or carrier bandwidth. The former search is motivated by group delay evidence that high and low frequency SSR responses originate from different sources (Ross et al, 2000;Schoonhoven et al, 2003). Another example might be the analogous search for narrowband SSR sources as a function of carrier frequency (tonotopy).…”

Section: Discussionmentioning

confidence: 99%

Fully complex magnetoencephalography

Simon

Wang

2005

Journal of Neuroscience Methods

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Complex numbers appear naturally in biology whenever a system can be analyzed in the frequency domain, such as physiological data from magnetoencephalography (MEG). For example, the MEG steady state response to a modulated auditory stimulus generates a complex magnetic field for each MEG channel, equal to the Fourier transform at the stimulus modulation frequency. The complex nature of these data sets, often not taken advantage of, is fully exploited here with new methods. Whole-head, complex magnetic data can be used to estimate complex neural current sources, and standard methods of source estimation naturally generalize for complex sources. We show that a general complex neural vector source is described by its location, magnitude, and direction, but also by a phase and by an additional perpendicular component. We give natural interpretations of all the parameters for the complex equivalent-current dipole by linking them to the underlying neurophysiology. We demonstrate complex magnetic fields, and their equivalent fully complex current sources, with both simulations and experimental data.

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“…Whereas the right hemisphere is thought to preferentially process syllabic-rate modulations (Abrams et al 2008;Hämäläinen et al 2012;Millman et al 2010), a bilateral (Hämäläinen et al 2012;Herdman et al 2003) or left hemispheric (Belin et al 1998;Jamison et al 2006;Johnsrude et al 1997) preference for phonemic-rate modulations is assumed. Results of prior studies on hemispheric asymmetry of ASSRs have been inconclusive (Hämäläinen et al 2012;Herdman et al 2002;Ross et al 2005;Schoonhoven et al 2003;Yamasaki et al 2005) and may be influenced by the nature of the stimulus (e.g., noise, pure tones), presentation parameters (e.g., monaural left/right ear, binaural or dichotic presentation), recording technique (EEG and MEG), and data analysis technique (scalp versus source analysis).…”

Section: Introductionmentioning

confidence: 99%

Hemispheric Asymmetry of Auditory Steady-State Responses to Monaural and Diotic Stimulation

Poelmans

Luts

Vandermosten

et al. 2012

JARO

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Amplitude modulations in the speech envelope are crucial elements for speech perception. These modulations comprise the processing rate at which syllabic (∼3-7 Hz), and phonemic transitions occur in speech. Theories about speech perception hypothesize that each hemisphere in the auditory cortex is specialized in analyzing modulations at different timescales, and that phonemic-rate modulations of the speech envelope lateralize to the left hemisphere, whereas right lateralization occurs for slow, syllabic-rate modulations. In the present study, neural processing of phonemic-and syllabic-rate modulations was investigated with auditory steady-state responses (ASSRs). ASSRs to speechweighted noise stimuli, amplitude modulated at 4, 20, and 80 Hz, were recorded in 30 normal-hearing adults. The 80 Hz ASSR is primarily generated by the brainstem, whereas 20 and 4 Hz ASSRs are mainly cortically evoked and relate to speech perception. Stimuli were presented diotically (same signal to both ears) and monaurally (one signal to the left or right ear). For 80 Hz, diotic ASSRs were larger than monaural responses. This binaural advantage decreased with decreasing modulation frequency. For 20 Hz, diotic ASSRs were equal to monaural responses, while for 4 Hz, diotic responses were smaller than monaural responses. Comparison of left and right ear stimulation demonstrated that, with decreasing modulation rate, a gradual change from ipsilateral to right lateralization occurred. Together, these results (1) suggest that ASSR enhancement to binaural stimulation decreases in the ascending auditory system and (2) indicate that right lateralization is more prominent for low-frequency ASSRs. These findings may have important consequences for electrode placement in clinical settings, as well as for the understanding of low-frequency ASSR generation.

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A whole head MEG study of the amplitude-modulation-following response: phase coherence, group delay and dipole source analysis

Cited by 59 publications

References 42 publications

Potential fMRI correlates of 40-Hz phase locking in primary auditory cortex, thalamus and midbrain

Potential fMRI correlates of 40-Hz phase locking in primary auditory cortex, thalamus and midbrain

Fully complex magnetoencephalography

Hemispheric Asymmetry of Auditory Steady-State Responses to Monaural and Diotic Stimulation

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