This paper presents a wide-band transmission line model for defected ground structures (DGSs) based on a mode-conversion between microstrip- and slot-lines. The defects on the ground plane are modeled as short- or open-ended transmission lines (TLs) with slot-line characteristics. The transition between microstrip line and ground defect is modeled with interdependent voltage and current sources, of which the first one is placed in series with the microstrip line, and the latter in-shunt with the slot lines, respectively. A complete set of geometry-dependent analytical expressions for the ABCD parameter of a two-port microstrip line crossing over the defected structure is provided. Therefore, the proposed model can be readily integrated into computer-aided design programs. The model’s accuracy is verified in various defect shapes by comparing its results with those from HFSS simulations and measurements.