A Window to Observe the Foreign Body Reaction to Glucose Sensors

Makale, Milan; Goor, Jared B.

doi:10.1002/9780470567319.ch4

Cited by 1 publication

(1 citation statement)

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“…One of the primary obstacles to practical, long-lasting, insertable biosensors is engineering a favorable foreign body response. The foreign body response plays a definitive role in a biosensors safety, performance, and longevity. , It begins with biofouling of the biomaterial surface, which is then quickly surrounded by immune cells and finally fibrotic encapsulation. Each of these steps progressively chokes off diffusion between the probe and the interstitial fluid.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response

Chimene,

Saleem,

Longbottom

et al. 2024

ACS Appl. Bio Mater.

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Phosphorescence-based oxygen-sensing hydrogels are a promising platform technology for an upcoming generation of insertable biosensors that are smaller, softer, and potentially more biocompatible than earlier designs. However, much remains unknown about their long-term performance and biocompatibility in vivo. In this paper, we design and evaluate a range of hydrogel sensors that contain oxygen-sensitive phosphors stabilized by micro- and nanocarrier systems. These devices demonstrated consistently good performance and biocompatibility in young adult rats for over three months. This study thoroughly establishes the biocompatibility and long-term suitability of phosphorescence lifetime sensors in vivo, providing the groundwork for expansion of this platform technology into a family of small, unobtrusive biosensors for a range of clinically relevant metabolites.

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Section: Introductionmentioning

confidence: 99%