A wireless and battery-free wound infection sensor based on DNA hydrogel

Xiong, Ze; Achavananthadith, Sippanat; Lian, Sophie Wan Mei; Madden, Leigh; Ong, Zi Xin; Chua, Wisely; Kalidasan, Viveka; Li, Zhipeng; Zhu, Liu; Singh, Priti; Yang, Haitao; Heussler, S. P.; Kalaiselvi, S. M. P.; Breese, Mark B. H.; Yao, Haicheng; Gao, Yu-Ji; Sanmugam, Kavitha; Tee, Benjamin C. K.; Chen, Po‐Yen; Loke, Weiqiang; Lim, Chwee Teck; Chiang, Grace Shu Hui; Tan, Boon Yeow; Li, Hao; Becker, David L.; Ho, John S.

doi:10.1126/sciadv.abj1617

Cited by 108 publications

(64 citation statements)

References 63 publications

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“…However, frequent and long-term hospitalization for monitoring can be impractical due to the high financial burden and poor patient adherence. Some efforts on wound monitoring [155][156][157][158] and responsive release of bioactive agents to wound sites 23,66,76,159 have been made, but hydrogels with the integrity of sensing and ondemand delivery in response to a dynamic wound environment remain a challenge. In addition, the development of customized bioactive hydrogels in the treatment of individual wounds can be a breakthrough in the future.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Mao

et al. 2022

J. Mater. Chem. B

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“…Selective degradation of the hydrogel occurs upon exposure to DNase, resulting in dielectric changes and providing the reporting signals for wound infection sensing. Reproduced with permission from ref . Copyright 2021 American Association for the Advancement of Science.…”

Section: Dna-based Hydrogels In Response To External Triggersmentioning

confidence: 99%

Recent Advances in Stimuli-Responsive DNA-Based Hydrogels

Wang

Zhang

2022

ACS Appl. Bio Mater.

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Stimuli-responsive DNA-based hydrogels are attracting growing interest because of their smart responsiveness, excellent biocompatibility, regulated biodegradability, and programmable design properties. Integration of reconfigurable DNA architectures and switchable supramolecular moieties (as cross-linkers) in hydrogels by responding to external stimuli provides an ideal approach for the reversible tuning structural and mechanical properties of the hydrogels, which can be exploited in the development of intelligent DNA-based materials. This review highlights recent advances in the design of responsive pure DNA hydrogels, DNA–polymer hybrid hydrogels, and autonomous DNA-based hydrogels with transient behaviors. A variety of chemically and physically triggered DNA-based stimuli-responsive hydrogels and their versatile applications in biosensing, biocatalysis, cell culture and separation, drug delivery, shape memory, self-healing, and robotic actuators are summarized. Finally, we address the key challenges that the field will face in the coming years, and future prospects are identified.

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Section: Introductionmentioning

confidence: 99%

“…The whole process could be controlled using mobile technologies with the possibility to have an electronic medical record and will constitute a personal point of care for patients. [28,29] Figure 1. Schematic representation of electrically responsive biocidal surface based on phosphonium self-assembled monolayers.…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand

Carrara

Rouvier

Auditto

et al. 2022

IJMS

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Prosthetic implants are widely used in dentistry and orthopedics and, as a result, infections can occur which cause their removal. Therefore, it is essential to propose methods of eradicating the bacteria that remain on the prosthesis during treatment. For this purpose, it is necessary to develop surfaces whose antibacterial activity can be controlled. Herein, we designed innovative and smart phosphonium self-assembled monolayer (SAM) interfaces that can be electrically activated on demand for controlling bacterial contaminations on solid surfaces. Upon electroactivation with a low potential (0.2 V for 60 min., conditions determined through a DOE), a successful stamping out of Gram-positive and Gram-negative bacterial strains was obtained with SAM-modified titanium surfaces, effectively killing 95% of Staphylococcus aureus and 90% Klebsiellapneumoniae. More importantly, no toxicity towards eukaryotic cells was observed which further enhances the biocompatible character of these novel surfaces for further implementation.

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A wireless and battery-free wound infection sensor based on DNA hydrogel

Abstract: A wireless sensor based on bioresponsive DNA hydrogel provides smartphone-based detection of wound infection.

Cited by 108 publications

References 63 publications

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

Recent Advances in Stimuli-Responsive DNA-Based Hydrogels

Nanoarchitectonics of Electrically Activable Phosphonium Self-Assembled Monolayers to Efficiently Kill and Tackle Bacterial Infections on Demand

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