A Wireless Fully Passive Neural Recording Device for Unobtrusive Neuropotential Monitoring

Kiourti, Asimina; Lee, Cedric W. L.; Chae, Junseok; Volakis, John L.

doi:10.1109/tbme.2015.2458583

Cited by 64 publications

(23 citation statements)

References 34 publications

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“…[412–413] Smaller, fully implantable wireless modules have been fabricated that can directly interface with commercially available neural probes. [414–417] These devices still require in vivo validation, but are a promising strategy to adapt mature technology to the next generation. Less invasive options include fully injectable millimeter scale electrodes which can interface with neural signal processors via radio-frequency (RF) or ultrasound.…”

Section: 0 Materials Considerations For Engineeringmentioning

confidence: 99%

A Materials Roadmap to Functional Neural Interface Design

Wellman

Eles

Ludwig

et al. 2017

Adv Funct Materials

309

328

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Advancement in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments, cures, and preventative measures for a variety of neurological disorders. The grand challenge in neural interface engineering is to seamlessly integrate the interface between neurobiology and engineered technology, to record from and modulate neurons over chronic timescales. However, the biological inflammatory response to implants, neural degeneration, and long-term material stability diminish the quality of interface overtime. Recent advances in functional materials have been aimed at engineering solutions for chronic neural interfaces. Yet, the development and deployment of neural interfaces designed from novel materials have introduced new challenges that have largely avoided being addressed. Many engineering efforts that solely focus on optimizing individual probe design parameters, such as softness or flexibility, downplay critical multi-dimensional interactions between different physical properties of the device that contribute to overall performance and biocompatibility. Moreover, the use of these new materials present substantial new difficulties that must be addressed before regulatory approval for use in human patients will be achievable. In this review, the interdependence of different electrode components are highlighted to demonstrate the current materials-based challenges facing the field of neural interface engineering.

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Section: 0 Materials Considerations For Engineeringmentioning

confidence: 99%

A Materials Roadmap to Functional Neural Interface Design

Wellman

Eles

Ludwig

et al. 2017

Adv Funct Materials

309

328

View full text Add to dashboard Cite

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“…We recorded evoked EMG responses from the gastrocnemius muscle of adult Long-Evans rats under anesthesia using the neural dust system. The mote was placed on the exposed muscle surface, the skin and surrounding connective tissue were then Biederman et al, 2013Muller et al, 2015Schwerdt et al, 2011Kiourti et al, 2016Charthad et al, 2015 replaced, and the wound was closed with surgical suture (Figure 4A). The ultrasonic transducer was positioned 8.9 mm away from the implant (one Rayleigh distance of the external transducer) and commercial ultrasound gel (Aquasonic 100, Parker Labs) was used to enhance coupling.…”

Section: Emg and Eng Can Be Recorded Tetherlessly In Vivo In Rodentsmentioning

confidence: 99%

Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust

Seo

Neely

Shen

et al. 2016

Neuron

476

339

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The emerging field of bioelectronic medicine seeks methods for deciphering and modulating electrophysiological activity in the body to attain therapeutic effects at target organs. Current approaches to interfacing with peripheral nerves and muscles rely heavily on wires, creating problems for chronic use, while emerging wireless approaches lack the size scalability necessary to interrogate small-diameter nerves. Furthermore, conventional electrode-based technologies lack the capability to record from nerves with high spatial resolution or to record independently from many discrete sites within a nerve bundle. Here, we demonstrate neural dust, a wireless and scalable ultrasonic backscatter system for powering and communicating with implanted bioelectronics. We show that ultrasound is effective at delivering power to mm-scale devices in tissue; likewise, passive, battery-less communication using backscatter enables high-fidelity transmission of electromyogram (EMG) and electroneurogram (ENG) signals from anesthetized rats. These results highlight the potential for an ultrasound-based neural interface system for advancing future bioelectronics-based therapies.

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“…Equation (9) highlights the relationship between wavelength in the medium and the radian length. For lossless media (σ = 0), the radian length r l simplifies to:…”

Section: Radian Length For Tissue Implanted Sourcementioning

confidence: 99%

“…Irrespective of the application it is clear that wireless communication with implanted medical devices is advantageous as it reduces the risk of infection [8] and offers much more flexibility in terms of selection of the implant site [5], [9]. Early medical implants utilized inductive coupling communication techniques but alignment concerns and the need for higher information rate operation led to studies at UHF Scanlon is with Tyndall National Institute, University College Cork (Ireland) and the remaining authors are with the Centre for Wireless Innovation, ECIT, Queen's University of Belfast (UK).…”

Section: Introductionmentioning

confidence: 99%

Assessing the Intrinsic Radiation Efficiency of Tissue-Implanted UHF Antennas

El-Saboni

Zelenchuk

Conway

et al. 2020

IEEE Trans. Antennas Propagat.

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Dielectric loss occurring in tissues in close proximity to UHF implanted antennas is an important factor in the performance of medical implant communication systems. Common practice in numerical analysis and testing is to utilize radiation efficiency measures external to the tissue phantom employed. This approach means that radiation efficiency is also dependent on the phantom used and antenna positioning, making it difficult to understand antenna performance and minimize near-field tissue losses. Therefore, an alternative methodology for determining the intrinsic radiation performance of implanted antennas that focuses on assessing structural and near field tissue losses is presented. The new method is independent of the tissue phantom employed and can be used for quantitative comparison of designs across different studies. The intrinsic radiation efficiency of an implant antenna is determined by assessing the power flow within the tissue phantom at a distance of at least λg/2 from the radiating structure. Simulated results are presented for canonical antennas at 403 MHz and 2400 MHz in homogeneous muscle and fat phantoms. These illustrate the dominance of propagating path losses in high-water content tissues such as muscle, whereas nearfield dielectric losses may be more important in low-water tissues such as fat due to the extended reactive near-field.

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A Wireless Fully Passive Neural Recording Device for Unobtrusive Neuropotential Monitoring

Abstract: The proposed recorder brings forward transformational possibilities in wireless fully passive neural detection for a very wide range of applications (e.g., epilepsy, Alzheimer's, mental disorders, etc.).

Cited by 64 publications

References 34 publications

A Materials Roadmap to Functional Neural Interface Design

A Materials Roadmap to Functional Neural Interface Design

Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust

Assessing the Intrinsic Radiation Efficiency of Tissue-Implanted UHF Antennas

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