A wireless neural interface for chronic recording

Harrison, R.R.; Kier, R.J.; Kim, Sohee; Rieth, Loren; Warren, David J.; Ledbetter, Noah M.; Clark, Gregory A.; Solzbacher, F.; Chestek, Cindy A; Gilja, Vikash; Nuyujukian, Paul; Ryu, Stephen I.; Shenoy, Krishna V.

doi:10.1109/biocas.2008.4696890

Cited by 17 publications

(12 citation statements)

References 6 publications

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“…The details of the system integration are described elsewhere [6]. An inductive wireless link provides power, clock and command signals to the chip.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

Sharma

Rieth

Tathireddy

et al. 2012

Sensors and Actuators A: Physical

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The encapsulation and packaging reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA)/integrated neural interface-recording version 5 (INI-R5) has been evaluated by monitoring the extended long term in-vitro functional stability and recording longevity. The INI encapsulated with 6-μm Parylene-C was immersed in phosphate buffer saline (PBS) at room temperature for a period of over 12 months. The USEA/INI-R5, while being soaked was powered and configured wirelessly through 2.765 MHz inductive link and the transmitted frequency shift keying (FSK) modulated radio-frequency (RF) (900 MHz Industrial, scientific, medical-ISM band) signal was also recorded wirelessly as a function of soak time. In order to test the long term recording ability, in-vitro wireless recording was performed in agarose for few channels. The full functionality and the ability of the electrodes to record artificial neural signals even after 12 months of PBS soak provides a measure of encapsulation reliability, the functional and recording stability in fully integrated wireless neural interface and potential usefulness for future chronic implants.

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“…The details of the system integration are described elsewhere [6]. An inductive wireless link provides power, clock and command signals to the chip.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

Sharma

Rieth

Tathireddy

et al. 2012

Sensors and Actuators A: Physical

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show abstract

“…A 100-channel wireless neural recording IC designated as INIR-5 (integrated neural interface recording version-5), was fabricated in a commercially available 0.6-μm 2P3M BiCMOS process at X-fab Semiconductors. The details of the system integration including design, fabrication and the chip design are described elsewhere [12, 16]. The INI-R5 IC was flip chip bonded to 10×10 USEA using Au/Sn reflow soldering.…”

Section: Methodsmentioning

confidence: 99%

“…In this context, the University of Utah has been developing fully integrated wireless neural interfaces capable of recording/stimulating neural activity from 100 electrodes. In a fully integrated wireless neural interface, an integrated circuit (IC) that is capable of amplifying, digitizing, and transmitting the neural data out wirelessly, is flip chip bonded to the backside of UEA/USEA [16, 17]. The power, clock and command signals to the IC are also supplied wirelessly via an inductive link [18].…”

Section: Introductionmentioning

confidence: 99%

Long termin vitrofunctional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array

et al. 2011

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We evaluate the encapsulation and packaging reliability of fully integrated wireless neural interface based on Utah Slant Electrode Array/integrated neural interface-recording version 5 (USEA/INI-R5) system by monitoring the long term in-vitro functional stability and recording longevity. The integrated neural interface (INI) encapsulated with 6 μm Parylene-C was immersed in phosphate buffered saline (PBS) for a period of over 276 days (with the monitoring of the functional device still ongoing). The full functionality (wireless radio-frequency power, command and signal transmission) and the ability of the electrodes to record artificial neural signals even after 276 days of PBS soaking with little change (within 14%) in signal/noise amplitude constitutes a major milestone in long term stability, and allows to study and evaluate the encapsulation reliability, functional stability, and its potential usefulness for wireless neural interface for future chronic implants.

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“…The ultimate goal in the future is to develop a medial implant allowing intracortical stimulation. The challenges of building such a fully implantable wireless system [82,83,84,85,86,87], [88,89] arise from the necessity to obey multiple constraints: the height is restricted, especially if the implant should be placed between the skull and the brain [90] for improving long term stability. Here, possible pressure to the brain tissue is an additional problem [91,92,93].…”

Section: Rhdmentioning

confidence: 99%

Open Hardware for neuro-prosthesis research: A study about a closed-loop multi-channel system for electrical surface stimulations and measurements

Rotermund

Ernst

Pawelzik

2017

Preprint

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Recent progress in neuro-prosthetic technology gives rise to the hope that in the future blind people might regain some degree of visual perception. It was shown that electrically stimulating the brain can be used to produce simple visual impressions of light blobs (phosphenes). However, this perception is very far away from natural sight. For developing the next generation of visual prostheses, real-time closed-loop stimulators which measure the actual neuronal activities and on this basis determine the required stimulation pattern. This leads to the challenge to design a system that can produce arbitrary stimulation-patterns with up to ±70V and with up to 25mA while measuring neuronal signals with amplitudes in the order of mV. Furthermore, the interruption of the measurement by stimulation must be as short as possible and the system needs to scale to hundreds of electrodes. We discuss how such a system and especially its current pumps and input protection need to be designed and which problems arise. We condense our findings into an example design for which we provide all design files (boards, firmwares and software) as open-source. This is a first step in taking the existing open-source www.open-ephys.org recording system and converting it into a closed-loop experimental setup for neuro-prosthetic research.

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A wireless neural interface for chronic recording

Cited by 17 publications

References 6 publications

Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

Long termin vitrofunctional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array

Open Hardware for neuro-prosthesis research: A study about a closed-loop multi-channel system for electrical surface stimulations and measurements

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