A wireless patch for the monitoring of C-reactive protein in sweat

Tu, Jiaobing; Min, June Kee; Song, Yu; Xu, Changhao; Li, Jiahong; Moore, Jeff; Hanson, Justin; Hu, Eugenia; Parimon, Tanyalak; Davoodi, Elham; Chou, Tsui‐Fen; Chen, Peter C.; Hsu, Jeffrey J.; Rossiter, Harry B.; Gao, Wei

doi:10.1038/s41551-023-01059-5

Cited by 118 publications

(55 citation statements)

References 60 publications

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“…134 Another recent work reports the continuous detection of C-reactive protein in sweat to monitor chronic inflammation in chronic obstructive pulmonary disease patients. 135 Similar concepts are in earlier stages of development for providing clinically relevant diagnostic information for other diseases including diabetes, 136 bacterial infections, 137,138 inflammatory bowel disease, 139 and cancer. 140 Continued advances in sensing capabilities will enable an expanded understanding of the clinical relevance of the timedynamic and activity-dependent variations of various sweat biomarker concentrations.…”

Section: ■ Emerging Applicationsmentioning

confidence: 89%

“…Conventional sweat tests must be performed in a centralized, certified testing facility by trained personnel; however, the recent development of low-cost wearable “sweat stickers” that support both collection and in situ chloride analysis holds promise for expanding access to CF diagnostic testing in a variety of settings (Figure C) . Another recent work reports the continuous detection of C-reactive protein in sweat to monitor chronic inflammation in chronic obstructive pulmonary disease patients . Similar concepts are in earlier stages of development for providing clinically relevant diagnostic information for other diseases including diabetes, bacterial infections, , inflammatory bowel disease, and cancer .…”

Section: Emerging Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Skin-Interfaced Wearable Sweat Sensors: Opportunities for Equitable Personalized Medicine and Global Health Diagnostics

Clark,

Ray

2023

ACS Sens.

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Recent advances in skin-interfaced wearable sweat sensors enable the noninvasive, real-time monitoring of biochemical signals associated with health and wellness. These wearable platforms leverage microfluidic channels, biochemical sensors, and flexible electronics to enable the continuous analysis of sweat-based biomarkers such as electrolytes, metabolites, and hormones. As this field continues to mature, the potential of lowcost, continuous personalized health monitoring enabled by such wearable sensors holds significant promise for addressing some of the formidable obstacles to delivering comprehensive medical care in under-resourced settings. This Perspective highlights the transformative potential of wearable sweat sensing for providing equitable access to cutting-edge healthcare diagnostics, especially in remote or geographically isolated areas. It examines the current understanding of sweat composition as well as recent innovations in microfluidic device architectures and sensing strategies by showcasing emerging applications and opportunities for innovation. It concludes with a discussion on expanding the utility of wearable sweat sensors for clinically relevant health applications and opportunities for enabling equitable access to innovation to address existing health disparities.

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Section: ■ Emerging Applicationsmentioning

confidence: 89%

Section: Emerging Applicationsmentioning

confidence: 99%

Recent Advances in Skin-Interfaced Wearable Sweat Sensors: Opportunities for Equitable Personalized Medicine and Global Health Diagnostics

Clark,

Ray

2023

ACS Sens.

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show abstract

“…The wearable patch was further equipped with an on-demand electroresponsive drug release system and enabled substantially accelerated chronic wound closure. The same group developed a flexible laser-engraved graphene (LEG)-AuNPs immunosensor for wireless monitoring of inflammatory biomarker C-reactive protein in sweat, realizing real-time electrochemical detection of chronic obstructive pulmonary disease . v-AuNW-based elastomeric conductors possessed intrinsic outstanding stretchability and have also been successfully used as soft wearable electrochemical electrodes toward glucose, lactate, or multiplexed sensing under a stretchable and mechanically deformable platform. , A mechanically gated electrochemical ionic channel was reported by virtue of thiolate ligand-exchanged v-AuNWs as stretchable electrodes toward hydrated redox ionic species (Figure c, d) .…”

Section: Ldn-based Wearable Sensorsmentioning

confidence: 99%

Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare

Gong,

Lu,

Yin

et al. 2024

Chem. Rev.

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In the era of Internet-of-things, many things can stay connected; however, biological systems, including those necessary for human health, remain unable to stay connected to the global Internet due to the lack of soft conformal biosensors. The fundamental challenge lies in the fact that electronics and biology are distinct and incompatible, as they are based on different materials via different functioning principles. In particular, the human body is soft and curvilinear, yet electronics are typically rigid and planar. Recent advances in materials and materials design have generated tremendous opportunities to design soft wearable bioelectronics, which may bridge the gap, enabling the ultimate dream of connected healthcare for anyone, anytime, and anywhere. We begin with a review of the historical development of healthcare, indicating the significant trend of connected healthcare. This is followed by the focal point of discussion about new materials and materials design, particularly low-dimensional nanomaterials. We summarize material types and their attributes for designing soft bioelectronic sensors; we also cover their synthesis and fabrication methods, including top-down, bottom-up, and their combined approaches. Next, we discuss the wearable energy challenges and progress made to date. In addition to front-end wearable devices, we also describe back-end machine learning algorithms, artificial intelligence, telecommunication, and software. Afterward, we describe the integration of soft wearable bioelectronic systems which have been applied in various testbeds in real-world settings, including laboratories that are preclinical and clinical environments. Finally, we narrate the remaining challenges and opportunities in conjunction with our perspectives.

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“…[1][2][3][4] The non-invasive detection of sweat at the molecular level using wearable electrochemical sensors for health monitoring and disease prevention has been extensively researched in recent years. [5][6][7] Glucose, lactic acid, and many other redox-active molecules (e.g., dopamine, uric acid) present in sweat can be detected using the amperometric method. Besides, various ions (Na + , K + , Ca 2+ , etc.)…”

Section: Introductionmentioning

confidence: 99%