2021
DOI: 10.12659/ajcr.930301
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A Woman with a 27-Year History of Hyperparathyroidism and Hypercalcemia Who Was Diagnosed with Low-Grade Parathyroid Carcinoma

Abstract: Patient: Female, 51-year-old (was first diagnosed as 23-year-old) Final Diagnosis: Parathyroid carcinoma Symptoms: Hypercalcemia • hypercalcemic shock • nephrolithiasis Medication: — Clinical Procedure: Pharmacological treatment • surgery and radiotherapy Specialty: Endocrinology and Metabolic • Oncology Objective: Rare disease Background: Parathyroid carcinoma (PC), accounting… Show more

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Cited by 5 publications
(6 citation statements)
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“…It often starts in people between 40 and 50 years old and affects men and women alike. (1,3,4) Pathogenesis is still unknown, and it can start sporadically or be associated with genetic syndromes like multiple endocrine neoplasm type 1, 2 (MEN 1, MEN 2), familial hyperparathyroidism. Non genetic factors associated with the disease are previous neck radiation, primary hyper-parathyroidism or thyroid cancer.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It often starts in people between 40 and 50 years old and affects men and women alike. (1,3,4) Pathogenesis is still unknown, and it can start sporadically or be associated with genetic syndromes like multiple endocrine neoplasm type 1, 2 (MEN 1, MEN 2), familial hyperparathyroidism. Non genetic factors associated with the disease are previous neck radiation, primary hyper-parathyroidism or thyroid cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Non genetic factors associated with the disease are previous neck radiation, primary hyper-parathyroidism or thyroid cancer. (1,2) The main symptom in the disease early stages is a lesion of progressive growth. This, however, in the context of a mass that seems to come from the thyroid leads to ruling out-as it was the case with our patient-the presence of a type of aggressive thyroid carcinoma without considering the possibility of a parathyroid malignant lesion.…”
Section: Discussionmentioning
confidence: 99%
“…An explanatory case of the unpredictability of this clinical entity has recently been reported. A 53-year-old woman, after a first lower right parathyroidectomy in 1993, experienced multiple relapses both in terms of hypercalcemic crisis and radiological recurrences, which required several surgeries, associated with radiotherapy and medical treatment, before reaching the histopathological criteria for the definitive diagnosis of PC ( 33 ).…”
Section: Discussionmentioning
confidence: 99%
“…Рак ПЩЗ зазвичай є спорадичним, але рідко може бути й частиною сімейних синдромів, таких як MEN1, MEN2A, ізольований сімейний ПГПТ [76]. Особливої уваги потребує підвищений ризик раку ПЩЗ при ПГПТ-JT [77][78][79]. Лікуванням вибору раку ПЩЗ є повна хірургічна резекція залоз, включаючи навколишні тканини та уникаючи розривів капсули [80].…”
Section: орфанні захворювання пщзunclassified