A young lady with swelling and stiffness of calf muscles

Kiran, H S; Murthy, K A Sudharshana; Aparna, A

doi:10.4103/2230-8210.81946

Cited by 5 publications

(7 citation statements)

References 2 publications

(8 reference statements)

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“…This suggests that continuous, spontaneous electrical activity of muscle could cause a true hypertrophy. [11][12][13][14][15][16] Kiran et al 17 reported a case of Hoffman syndrome, a rare form of hypothyroid myopathy, with proximal weakness and pseudohypertrophy of muscles, thought to be secondary to accumulation of glycosaminoglycans.…”

Section: Discussionmentioning

confidence: 99%

Macroglossia in Amyotrophic Lateral Sclerosis

et al. 2013

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n amyotrophic lateral sclerosis (ALS), hypoglossal motor neurons degenerate. This is recognized clinically by dysarthria and difficulty manipulating food in the oropharynx to initiate swallowing. Usual findings on examination include tongue atrophy, weakness, fasciculations, pseudobulbar affect in some, and spasticity of jaw musculature. 1 In this case report, we describe 2 atypical ALS cases with enlargement of the tongue (macroglossia).

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Section: Discussionmentioning

confidence: 99%

Macroglossia in Amyotrophic Lateral Sclerosis

et al. 2013

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“…El retraso en la contracción y relajación muscular puede deberse a la redistribución de fibras de contracción rápida a contracción lenta. [3][4] Los grupos musculares más comúnmente involucrados son: la lengua y las extremidades superiores e inferiores. 2 En la figura 1 se aprecia la hipertrofia muscular a nivel de brazo, muslos y pantorrillas del paciente al ingreso, y la disminución de volumen luego de 35 días de tratamiento sustitutivo hormonal.…”

Section: Discussionunclassified

“…Las manifestaciones de hipotiroidismo que llevan a distintos tipos de neuropatía y miopatía son responsables únicamente del 5% de todas las miopatías adquiridas. 4 Por lo que el diagnóstico diferencial debe incluir las principales causas de debilidad muscular, (figura 2).…”

Section: Discussionunclassified

Síndrome de Hoffman: reporte de un caso de miopatía tiroidea

et al. 2020

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El hipotiroidismo primario constituye el 95% de las insuficiencias tiroideas. Este se presenta con diversas manifestaciones, entre ellas la debilidad simétrica proximal e hipertrofia muscular conocida como síndrome de Hoffman. Dicha patología se reporta únicamente en el 10% de casos, por lo que realizar el diagnóstico diferencial de debilidad muscular es indispensable. A continuación se relata el caso de un paciente de 69 años que consulta por debilidad muscular proximal progresiva, mialgias, dislalia y somnolencia; durante su hospitalización fue diagnosticado con tiroiditis de Hashimoto y miopatía hipotiroidea hipertrófica del adulto.

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“…True myopathy is a primary muscle involvement characterized by slowed muscle contraction and relaxation, muscle pain, proximal muscle weakness, sluggish ankle jerks and absence of sensory involvement 6 . Pain on muscle exertion is due to defective carbohydrate metabolism 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Literature search shows that the prominence of muscle symptoms correlates fairly closely with the degree and duration of hypothyroidism 6 and the serum CK level may be elevated in hypothyroidism: and can be an important differential diagnosis for raised serum CK. Case reports 6,7 shows that hypothyroidism can present with muscular symptoms alone with minimal or without any classical symptoms and signs of hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Study of Serum Creatine Kinase and Lactate Dehydrogenase to Assess Muscular Involvement in Hypothyroidism

Reena¹,

Ks²,

Ks³

et al. 2019

Indian Journal of Medical Biochemistry

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Background: Hypothyroidism is one of the most commonly occurring endocrine disorders, worldwide. The disorder is associated with a wide range of muscular involvement varying from myalgia to true myopathy. Biochemical parameters such as serum Creatine Kinase (CK), a sensitive marker of muscle damage and serum Lactate Dehydrogenase (LDH), a general marker of tissue damage can be measured to assess the muscular involvement in hypothyroidism. In this study serum CK and LDH activities to assess the muscular involvement in hypothyroidism and to evaluate their relationship with T 3 , T 4 and TSH. Materials and methods: Fifty, clinically diagnosed hypothyroidism patients with symptoms suggestive of muscle involvement were taken as cases and fifty sex and age matched, apparently healthy volunteers with normal thyroid function tests (TFT) were taken as controls. Biochemical estimations of triiodothyronine (T 3 ), thyroxine (T 4 ), thyroid stimulating hormone (TSH), serum CK and serum LDH were done. Results: T 3 , T 4 levels and serum CK and LDH activities were within the reference range in both the study groups. In seven cases high TSH with low T 4 values were observed. Significant difference in serum CK and LDH activities were observed in these seven cases compared to rest of the forty-three cases. Even though there was no significant difference among the study groups (cases and controls), a weak positive correlation of CK, LDH with TSH levels and weak negative correlation with T 3 and T 4 levels were observed. Conclusion: Hormone replacement therapy shall be optimized to treat muscular involvement if serum CK and LDH activity is found to be elevated with low T 4 levels, where as normal serum CK and LDH activity with normal T 4 levels indicates that the thyroid treatment is optimized (serum T 3 and T 4 levels has come to the reference range though TSH is mildly elevated) and if the subject is still complaining of muscular symptoms, then other underlying causes for muscular involvement shall be ruled out.

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A young lady with swelling and stiffness of calf muscles

Abstract: Hypothyroidism causes a variety of changes in the body. Though uncommon, hypothyroidism can present as myopathy. Hoffman's syndrome is a specific, rare form of hypothyroid myopathy, which causes proximal weakness and pseudohypertrophy of muscles.

Cited by 5 publications

References 2 publications

Macroglossia in Amyotrophic Lateral Sclerosis

Macroglossia in Amyotrophic Lateral Sclerosis

Síndrome de Hoffman: reporte de un caso de miopatía tiroidea

Study of Serum Creatine Kinase and Lactate Dehydrogenase to Assess Muscular Involvement in Hypothyroidism

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