A Young Man Presenting with Acute Encephalopathy, Hemiparesis, and Headache

Weng, Tzu Hsuan; Chiu, Wen Ta; Afilalo, Marc; Choy, Cheuk Sing; Tselios, Chris; Yip, Ping Keung; Lam, Carlos

doi:10.1016/j.jemermed.2009.07.032

Cited by 4 publications

(7 citation statements)

References 17 publications

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“…Familial hemiplegic migraine (FMH) is a rare (5/100 000), autosomal dominant disease, the subtypes of which are caused by mutation on the CACNA1A, ATP1A2, SCN1A or PRRT2 genes [34, 100, 101]. FHM is characterized by reversible motor weakness, which may resemble stroke or transient ischemic attack [29].…”

Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

Migraine and Stroke: What’s the Link? What to Do?

Gryglas

Śmigiel

2017

Curr Neurol Neurosci Rep

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Migraine and stroke are common, disabling neurologic disorders, with a high socioeconomic burden. A link between them has been proposed years ago, and various theories have been proposed to explain this bidirectional relation. However, the precise causes remain unclear. We briefly summarize existing hypotheses of this correlation seeking for recommendations for stroke prevention in migraineurs, if any exist. Among the strongest suggested theories of migraine–stroke association are cortical spreading depression, endovascular dysfunction, vasoconstriction, neurogenic inflammation, hypercoagulability, increased prevalence of vascular risk factors, shared genetic defects, cervical artery dissection, and patent foramen ovale. There is no evidence that any preventive therapy in migraineurs should be used to decrease stroke risk, even in most predisposed subset of patients. However, a woman with migraine with aura should be encouraged to cease smoking and avoid taking oral contraceptives with high estrogen doses. We need further investigation to better understand the complexity of migraine–stroke association and to make firm recommendations for the future.

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Section: The Underlying Mechanisms Of Coincidence Migraine and Strokementioning

confidence: 99%

Migraine and Stroke: What’s the Link? What to Do?

Gryglas

Śmigiel

2017

Curr Neurol Neurosci Rep

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“…HM is differentiated into FHM and sporadic HM, according to the presence or absence of familiarity [ 3 ]. HM can be easily misdiagnosed at its first presentation as an atypical severe form of migraine, a stroke, multiple sclerosis, metabolic/toxic disorders, conversion disorder or an epilepsy (Jacksonian march, Todd's paralysis) [ 4 , 9 ]. The clinical diagnosis is also rendered difficult, as migraine, epilepsy and HM share not solely clinical, but also pathophysiological similarities.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last 10 years, there have been several reports on this disease. Weng et al [ 4 ] reported the case of a 24-year-old male student who presented with general weakness that subsequently shifted to the right side associated with throbbing headache, right-sided hemianesthesia, hemianopia and facial palsy. Brain imaging (CT) was normal.…”

Section: Discussionmentioning

confidence: 99%

“…Both have similar clinical symptoms, except the latter is without familiarity [ 3 ]. The prevalence of FHM is low (0.005%) [ 4 ]. FHM is a genetically heterogeneous condition.…”

Section: Introductionmentioning

confidence: 99%

“…Mutations in four different genes, each characterizing the four familial forms (CACNA1A/FHM1, ATP1A2/FHM2, SCN1A/FHM3, PRRT2/FHM4) were identified; these genes are involved in encoding ion transporter proteins [ 5 , 6 ]. These mutated genes are the cause of an altered neuronal excitability and reduced threshold value for cortical spreading depression (CSD), a transient slow wave of profound neuronal and glial depolarization, which spreads over the brain hemispheres or in certain cases affects the brain stem being responsible for the brain stem symptoms in FHM; CSD is also supposed to be responsible for the migrainous aura in HM [ 4 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report

2016

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Hemiplegic migraine is a rare and complex disease, characterized by migraine with a reversible motor aura. Hemiplegic migraine can be easily misdiagnosed at its first presentation with an atypical severe form of migraine, a stroke, multiple sclerosis, metabolic disorders, conversion disorder or an epilepsy. We present the case of a young 24-year-old male patient, who since the age of 4 years had been having multiple episodes of migraine associated with hemiparesis, paraesthesia, prolonged somnolence, aphasia and confusion. We review the literature and discuss important diagnostic findings in hemiplegic migraine to help establishing a prompt diagnosis.

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Unusual Presentation of a Hemiplegic Migraine in a Seven-Year-Old Child: A Case Report

Alebaji¹,

Ani²,

Rozieh³

et al. 2023

Cureus

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In the pediatric population, headache is a common presenting symptom, and migraine is often the diagnosis. A hemiplegic migraine is characterized by an aura and sudden-onset weakness on one side of the body that usually resolves without causing any permanent neurological damage. In this case, we present a seven-yearold male child with a known case of proximal tubular dysfunction (homozygous mutation in the SLC4A4 gene) who presented to the emergency department with a one-day history of weakness on the right side of his body. A few hours after being discharged from the hospital, he began complaining of a severe headache on the left side, accompanied by photophobia, phonophobia, and high fever. Radiology scans and laboratory workup were unremarkable, and encephalitis was ruled out. He was later diagnosed with hemiplegic migraine based on his history and clinical presentation.

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A Young Man Presenting with Acute Encephalopathy, Hemiparesis, and Headache

Cited by 4 publications

References 17 publications

Migraine and Stroke: What’s the Link? What to Do?

Migraine and Stroke: What’s the Link? What to Do?

Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report

Unusual Presentation of a Hemiplegic Migraine in a Seven-Year-Old Child: A Case Report

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