A young woman concerned about mercury

Kales, Stefanos N.; Thompson, Aaron

doi:10.1503/cmaj.150669

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…A systematic review mentioned that long-chain omega-3 fatty acids in a high-fish diet can delay cognitive decline in elderly individuals, without dementia [37]. The serum Hg levels of our subjects were within the normal range, thus indicating a normal dietary intake (normal value: <20 µg/L for women aged ≥ 50 years and men aged > 18 years) [38]. Nonetheless, ICP-MS can only detect total Hg and fails to distinguish between the organic and inorganic forms.…”

Section: Discussionmentioning

confidence: 54%

A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study

Lin

Liang

Tsai

et al. 2022

JCM

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Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis; however, the potential of trace metal biomarkers in predicting cognitive decline has not been evaluated. This study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or AD. Participants (9 controls, 23 aMCI due to AD, and 8 AD dementia) underwent comprehensive cognitive tests, including the Mini-Mental State Examination (MMSE) and trace metal analysis. The correlations between the plasma trace element levels and annual MMSE changes during follow-up were analyzed. We found that an increase in disease severity was linked to lower plasma levels of boron (B), bismuth (Bi), thorium (Th), and uranium (U) (adjusted p < 0.05). Higher baseline calcium levels (r = 0.50, p = 0.026) were associated with less annual cognitive decline; those of B (r = −0.70, p = 0.001), zirconium (r = −0.58, p = 0.007), and Th (r = −0.52, p = 0.020) with rapid annual cognitive decline in the aMCI group; and those of manganese (r = −0.91, p = 0.035) with rapid annual cognitive decline in the AD group. Overall, our exploratory study suggests that plasma metal levels have great potential as in vivo biomarkers for aMCI and AD. Larger sample studies are necessary to confirm these results.

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Section: Discussionmentioning

confidence: 54%

A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study

Lin

Liang

Tsai

et al. 2022

JCM

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“…A systemic review mentioned that long-chain omega-3 fatty acids in a high-sh diet can delay cognitive decline in elderly individuals, without dementia [33]. The serum "Hg" levels of our subjects was within the normal range, thus indicating a normal dietary intake (normal value: <20µg/L for women aged ≥ 50 years and men aged > 18 years) [34]. Nonetheless, ICP-MS can only detect total "Hg" and fails to distinguish between the organic and inorganic forms.…”

Section: Discussionmentioning

confidence: 55%

A Metallomic Approach to Assess the Associations between Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-sectional and Longitudinal Study

Lin¹,

Liang²,

Tsai³

et al. 2021

Preprint

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BACKGROUND Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis. The present study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or AD. METHODS All participants (controls, aMCI, and AD) underwent baseline cognitive tests, which included the Mini-Mental State Examination (MMSE) and plasma biomarker examinations. We conducted a trend analysis for the cognitive tests and plasma trace elements and examined the correlations between the latter and annual MMSE changes during follow-up. RESULTS An increase in the disease severity was linked to lowered boron (B), bismuth (Bi), thorium (Th), and uranium (U) plasma concentrations (adjusted P < 0.05). “B”, mercury (Hg) and “Th” levels could detect different cognitive stages. “B” displayed high area under the receiver operating characteristic curves (AUCs) for aMCI and AD versus controls (97.6%, cut-off value: ≤73.1 ug/l and 100%, cut-off value: ≤47.1 ug/l, respectively). “Hg” displayed the highest AUC result to differentiate AD from aMCI (79.9%, cut-off value: ≤1.02 ug/l). Higher baseline levels of calcium (r = 0.50, p = 0.026) were associated with less annual cognitive decline. While higher baseline levels of “B” (r=-0.70, p = 0.001), zirconium (r=-0.58, p = 0.007), “Th” (r=-0.52, p = 0.020) were associated with rapid annual cognitive decline in the aMCI group, those of manganese (r=-0.91, p = 0.035) were associated with rapid annual cognitive decline in the AD group. CONCLUSION Plasma metal level biomarkers can be used as an in vivo tool to study and identify patients with aMCI and AD.

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“…Mercury in its three formselemental, inorganic, and organicmay cause toxicity [4][5][6][7][8] (Table 1). Toxicity differs by type and acuity of exposure.…”

Section: Commentarymentioning

confidence: 99%

The “wing-heeled” traveler

Kain

Weinstein

Thompson

et al. 2020

Trop Dis Travel Med Vaccines

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Intoxication syndromes may be travel acquired, and are related to intentional or accidental inhalational or percutaneous exposures or ingestions. Due to their myriad clinical presentations, initial differential diagnosis of such intoxications in returned travelers is broad, and typically requires detailed history and laboratory investigations to disentangle. We herein use a case-based clinical problem solving approach to illumination of a mercury intoxication syndrome, which presented in a 48-year-old VFR traveler to Guyana. Common clinical presentations, differential diagnoses, laboratory investigations, and therapeutic interventions are discussed.

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A young woman concerned about mercury

Cited by 4 publications

References 11 publications

A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study

A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study

A Metallomic Approach to Assess the Associations between Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: A Cross-sectional and Longitudinal Study

The “wing-heeled” traveler

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