The paper presents an interactive cardio system that can be used to improve healthcare. The proposed system receives, processes, and analyzes cardio data using an Internet-based software platform. The system enables the acquisition of biomedical data using various means of recording cardiac signals located in remote locations around the world. The recorded discretized cardio information is transmitted to the system for processing and mathematical analysis. At the same time, the recorded cardio data can also be stored online in established databases. The article presents the algorithms for the preprocessing and mathematical analysis of cardio data (heart rate variability). The results of studies conducted on the Holter recordings of healthy individuals and individuals with cardiovascular diseases are presented. The created system can be used for the remote monitoring of patients with chronic cardiovascular diseases or patients in remote settlements (where, for example, there may be no hospitals), control and assistance in the process of treatment, and monitoring the taking of prescribed drugs to help to improve people’s quality of life. In addition, the issue of ensuring the security of cardio information and the confidentiality of the personal data of health users is considered.