A Zn azelate MOF: combining antibacterial effect

Abstract

A novel biocompatible and bioactive zinc azelate metal–organic framework (BioMIL-5) was hydrothermally synthesized with interesting long-term antibacterial properties.

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“…Biorąc pod uwagę dużą liczbę dotychczas zsyntetyzowanych MOF-ów, w któ-rych cynk stanowi frakcję nieorganiczną, wykorzystanie ich właściwości przeciwdrobnoustrojowych może być interesującym kierunkiem badań nad biomedycznym zastosowaniem [29].…”

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“…Regarding the stability tests, BioMIL-5 has shown to be stable in water and in bacterial culture medium, but especially in water, leading to the progressive release of both Zn 2+ and azelaic acid. Indeed, this progressive and slow release of the active Zn 2+ and azelaic acid in both media led to interesting and time-maintained antibacterial properties when used for 7 days against S. epidermidis [91]. The high stability demonstrated and the maintenance of its antibacterial properties (Figure 1) turn BioMIL-5 into a promising candidate for future applications in the treatment of several skin disorders and in the cosmetic industry [91].…”

“…As previously mentioned, one of the best approaches to construct BioMOFs is the direct incorporation of therapeutically active molecules containing multiple complexing groups with biocompatible metal cations (Ca ), and thus the delivery of the active compounds is accomplished via framework degradation [25,91,[94][95][96][97]. Tamames-Tabar et al recently discussed the possibility of directly introducing azelaic acid as linker and an endogenous low-toxicity transition metal cation (Zn 2+ ) [98].…”

“…In the antibacterial activity studies, the MIC/MBC (MIC = minimal inhibitory concentration; MBC = minimal bactericidal concentration) values in S. aureus and S. epidermidis demonstrate that the antimicrobial activity of azelaic acid and Zn 2+ is maintained after the synthesis [91]. Regarding the stability tests, BioMIL-5 has shown to be stable in water and in bacterial culture medium, but especially in water, leading to the progressive release of both Zn 2+ and azelaic acid.…”

“…Both linker and metal exhibit interesting antibacterial and dermatological properties for the dermatological treatment of several skin disorders and their combination results into a novel biocompatible and bioactive MOF, named BioMIL-5. It was synthesized by hydrothermal methods and its stability was assessed through tests in water and in bacteria broth at 37°C; also antibacterial activity studies against two Grampositive bacteria Staphylococcus aureus and Staphylococcus epidermidis were conducted [91].…”