A β-cyclodextrin covalent organic framework used as a chiral stationary phase for chiral separation in gas chromatography

Tang, Bo; Wang, Wei; Hou, Huipeng; Liu, Yiquan; Liu, Zongkun; Li, Geng; Sun, Liquan; Luo, Aoxue

doi:10.1016/j.cclet.2021.06.089

Cited by 75 publications

(32 citation statements)

References 36 publications

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“…The massive hydroxyl and amino groups on the skeleton are amenable to carry out modification. It has been reported that β-CD COFs have excellent enantioseparation performance as CSP in high-performance liquid chromatography (HPLC), gas chromatography, and capillary electrochromatography (CEC). , To further broaden the versatility of the separated drugs and improve the separation efficiency, we propose two functional post-modification schemes to construct novel β-CD COFs in this work.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

Qiu

et al. 2022

ACS Appl. Mater. Interfaces

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β-Cyclodextrin covalent organic frameworks (β-CD COFs) show great potential in enantioseparation due to their uniformly distributed chiral recognition sites and good chemical stability. The hydroxyl and amino groups of β-CD COFs enable facile post-modification to introduce the desired functionality into the frameworks. In this study, we perform post-modification of β-CD COF BPDA with 1,4-butane sultone and [(3R,4R)-4-acetyloxy-2,5-dioxooxolan-3-yl] acetate to construct two kinds of novel functional β-CD COFs. The capillary columns prepared with these two functional β-CD COFs separated chiral dihydropyridines and fluoroquinolones with excellent selectivity and repeatability in capillary electrochromatography, while β-CD COF BPDA -modified capillary columns did not present the chiral recognition ability for these drugs. The mechanism of chiral recognition and the enhanced enantioselectivity of functional β-CD COFs were further demonstrated by molecular docking simulation. The divergent chiral separation performances of β-CD COFs suggest that the introduction of functional groups enables the modification of β-CD COF properties and tuning of its chiral recognition abilities for the diversity of enantioseparation.

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Section: Introductionmentioning

confidence: 99%

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

Qiu

et al. 2022

ACS Appl. Mater. Interfaces

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“…However, chromatography is unsuitable for on-site direct detection because of its complex steps, heavy equipment, and need for professional operators. 19,20 Electrochemical analysis has the advantages of portability, simplicity of operation, low secondary pollution, 21−23 and integration of various analytical techniques such as cyclic voltammetry (CV), square-wave voltammetry (SWV), square-wave adsorptive stripping voltammetry (SW-AdSV), differential pulse voltammetry (DPV), and linear sweep voltammetry (LSV).…”

Section: Introductionmentioning

confidence: 99%

“…Commonly used detection methods for CAP include liquid chromatography–tandem mass spectrometry (LC–MS/MS), surface-enhanced Raman scattering (SERS), gas chromatography–mass spectrometry (GC–MS), , and fluorescent and electrochemical methods. However, chromatography is unsuitable for on-site direct detection because of its complex steps, heavy equipment, and need for professional operators. , Electrochemical analysis has the advantages of portability, simplicity of operation, low secondary pollution, − and integration of various analytical techniques such as cyclic voltammetry (CV), square-wave voltammetry (SWV), square-wave adsorptive stripping voltammetry (SW-AdSV), differential pulse voltammetry (DPV), and linear sweep voltammetry (LSV).…”

Section: Introductionmentioning

confidence: 99%

Cu Nanoparticle-Decorated Boron–Carbon–Nitrogen Nanosheets for Electrochemical Determination of Chloramphenicol

Peng

Jia

et al. 2022

ACS Appl. Mater. Interfaces

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In the present work, irregular Cu nanoparticle-decorated boron−carbon−nitrogen (Cu−BCN) nanosheets were successfully synthesized. A Cu−BCN dispersion was deposited on a bare glassy carbon electrode (GCE) to prepare an electrochemical sensor (Cu−BCN/GCE) for the detection of chloramphenicol (CAP) in the environment. Cu−BCN was characterized using high-resolution scanning transmission electron microscopy (HRSTEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, and X-ray photoelectron spectroscopy (XPS). The performance of the Cu−BCN/GCE was studied using electrochemical impedance spectroscopy (EIS), and its advantages were proven by electrode comparison. Differential pulse voltammetry (DPV) was used to optimize the experimental conditions, including the amount of Cu−BCN deposited, enrichment potential, deposition time, and pH of the electrolyte. A linear relationship between the CAP concentration and current response was obtained under the optimized experimental conditions, with a wide linear range and a limit of detection (LOD) of 2.41 nmol/L. Cu−BCN/GCE exhibited high stability, reproducibility, and repeatability. In the presence of various organic and inorganic species, the influence of the Cu−BCN-based sensor on the current response of CAP was less than 5%. Notably, the prepared sensor exhibited excellent performance in real-water samples, with satisfactory recovery.

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“…Since covalent organic frameworks (COFs) were initially reported in 2005 by Yaghi, 1 COFs as a burgeoning class of nanoporous and crystalline materials were customarily constructed by linking building blocks through stable covalent bonds. [2][3][4][5] Their intriguing structural nature, such as the designability of the unit structure, highly ordered channels, tunable porous sizes, as well as excellent thermal and chemical stability, endows them with tremendous interest in gas sorption, 6 separation, 7,8 catalysis, 9,10 electronics, 11,12 sensors, 13,14 batteries, 15 photocatalytics 16,17 and so forth. Specifically, COFs as adsorbing materials have been extensively exploited for the selective removal of organic dyes from polluted water in view of their large surface areas and superb visible light absorbance based on the different interactions between dye molecules and COF surfaces: for example, electrostatic interaction, p-p stacking interaction and hydrogen bonding.…”

Section: Introductionmentioning

confidence: 99%

Multi-sulfonated functionalized hydrophilic covalent organic framework for highly efficient dye removal from real samples

Zhao

et al. 2022

New J. Chem.

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A β-cyclodextrin covalent organic framework used as a chiral stationary phase for chiral separation in gas chromatography

Cited by 75 publications

References 36 publications

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

Enhanced Chiral Recognition Abilities of Cyclodextrin Covalent Organic Frameworks via Chiral/Achiral Functional Modification

Cu Nanoparticle-Decorated Boron–Carbon–Nitrogen Nanosheets for Electrochemical Determination of Chloramphenicol

Multi-sulfonated functionalized hydrophilic covalent organic framework for highly efficient dye removal from real samples

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