A060 Māori and Pacific Patients With Non-Ischaemic Cardiomyopathy, Undergoing Cardiac Magnetic Resonance Imaging Have Worse Clinical Outcomes than European Patients

Abstract

Background: Cardiac Magnetic Resonance (CMR) imaging is increasingly utilised to assess the aetiology and severity of cardiomyopathies. Non-ischaemic cardiomyopathy (NICM) is a heterogeneous condition, with varying clinical and demographic factors influencing outcome. This study assesses differences in clinical outcomes in European compared with M aori and Pacific NICM patients undergoing CMR in South Auckland.Method: CMR reports from Counties Manukau District Health Board region (2005 -2019) were analysed from an ANZACS-QI linked CMR database. 536 patients with a diagnosis of NICM were identified and linked ethnicity data recorded. 498 patients were grouped according to European (n = 231) vs M aori and Pacific ethnicity (n = 267). Clinical, biochemical, imaging and demographic data was collected from electronic medical records. The primary end point was combined all cause mortality and readmission rate for decompensated heart failure.Results: M aori and Pacific patients were younger (52.3 +/-11.6 vs 57.2 +/-14.6 years, p,0.001), had higher Body Mass Index (36.7 kg/m 2 vs 29.5 kg/m 2 , p,0.001), and weight (105.3kg vs 87.4kg, p,0.001). CMR markers of left ventricular (LV) volumes (p=0.95), LV ejection fraction (p=0.14), and presence of myocardial fibrosis (p=0.13) were similar between the two groups. Implantable Cardiac Defibrillator, and Cardiac Resynchronisation Therapy implantation rates were similar (p=0.58). The primary combined outcome of readmission for decompensated heart failure and all cause mortality was significantly higher in M aori and Pacific patients (96 vs 48, p,0.001).Conclusion: M aori and Pacific patients with NICM have worse clinical outcomes than European patients, despite similar disease severity on CMR.