A179 Prevalence of Chronic Diarrhea Amongst Patients Followed in Gastroenterology

Daoud, Dane Christina; Bouin, Mickaël; Bellemare, L; Nemer, Mona

doi:10.1093/jcag/gwy009.179

Cited by 3 publications

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“…A high prevalence of GI symptoms in MEN2A patients has previously been reported, yet our cohort highlighted abdominal pain 85% ( n = 49), diarrhoea 85% ( n = 49) and constipation 75% ( n = 43). The burden of diarrhoea in MEN2A patients was comparable to untreated Crohn's disease (64%) or ulcerative colitis (89%) reported in other studies 13,14 . There was no difference in the severity of diarrhoea between people reporting high and normal calcitonin (mean score of 2 ± 1.16 vs. 2 ± 1.1).…”

Section: Discussionsupporting

confidence: 74%

Impact of gastrointestinal symptoms on quality of life in MEN2

Goncharova

Grey²,

Druce

2020

Clinical Endocrinology

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Context Besides medullary thyroid carcinoma and other endocrinopathies, people with Multiple Endocrine Neoplasia Type 2 (MEN2) are at risk of gastrointestinal (GI) symptoms. Objective To investigate the impact of GI symptoms on the daily lives of patients with MEN2. Design An online survey was conducted among patients with MEN2 via the Association for Multiple Endocrine Neoplasia Disorders (AMEND). Methods The survey incorporated two validated questionnaires for the assessment of GI symptoms (SAGIS, PAC‐QoL). Participants There were 91 respondents, MEN2A (n = 57), MEN2B (n = 34). Results People in the MEN2A group reported a high level of GI symptoms, the most prevalent being abdominal pain 85% (n = 49), diarrhoea 85% (n = 49) and constipation 75% (n = 43) with one patient having a SAGIS score > 10/12 in the constipation domain. People in the MEN2B group reported constipation in 79% (n = 27) with one quarter of these scoring > 10/12 in the constipation domain. Other GI symptoms included diarrhoea 62% (n = 21), excessive gas and flatulence (79%), epigastric pain (59%) abdominal cramps (76%) and dysphagia (41%). The effect of constipation on quality of life was severe in all MEN2 patients as measured by PAC‐QOL and all patients reported dissatisfaction of with their current treatment for constipation. There was a trend towards higher severity of GI symptoms in MEN2B. Conclusions We report unmet needs of patients with MEN2 syndromes. The GI symptoms, especially constipation, had a severe impact on quality of life in people with MEN2. This suggests that there is room for improvement in the quality of care offered for these patients.

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Section: Discussionsupporting

confidence: 74%

Impact of gastrointestinal symptoms on quality of life in MEN2

Goncharova

Grey²,

Druce

2020

Clinical Endocrinology

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“…3 A Canadian study showed that the prevalence of chronic diarrhea was 29%, with a mean age of 48.6 years. 4 There are no data on the majority of chronic diarrhea in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Rasdianto

Nugraha

Usman

et al. 2022

InaJGHE

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Background: Diagnosis and treating patients with chronic diarrhea are challenging due to broad differential diagnoses. An adequate examination leads to a specific diagnosis and appropriate management. Colonoscopy with biopsy is indicated to establish chronic diarrhea etiologies. No previous data demonstrated the colonoscopy and histology findings in patients with chronic diarrhea at Dr. Hasan Sadikin Bandung General Hospital, the main referral hospital in West Java. This study aims to determine the features of colonoscopy and histology in patients with chronic diarrhea.Method: This was a cross-sectional, descriptive study from secondary data of colonoscopy examinations at Dr. Hasan Sadikin Hospital General Hospital from 2016 to 2019. The inclusion criteria were patients with chronic diarrhea diagnosis, aged 18 years and over, and completed colonoscopy and biopsy results.Results: A total of 182 subjects with chronic diarrhea were included. Most subjects were women (52%) with an average age of 46 years. The clinical finding at admission was chronic diarrhea without hematochezia (75%). Meanwhile, 52% of colonoscopy lesions were multiple, with the anal-rectum segment (15%) being the most involved. Colonoscopy features mostly hyperemic or edematous lesions (58%). The histopathological result from this study revealed that 59% were non-specific chronic colitis (NSCC). Specific histopathological features were primarily found in malignancies (14%), and inflammatory bowel disease (12%).Conclusion: Chronic diarrhea without hematochezia was the most common objective for referring patients to colonoscopy. The hyperemic mucous lesion was mostly found. Moreover, the NSCC was frequent in histopathological evaluation, followed by malignancies and IBD.

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“…Malabsorption is impairment in absorption of nutrients caused by any disruption in the process of normal absorption at luminal, brush border processing and absorption into the intestinal mucosa or transport into the circulation. Diseases involving the mucosal brush border are celiac disease, giardiasis, tropical sprue 7 . A number of studies have done on the spectrum of the diseases related to chronic diarrhea in the general population 8 , and acute diarrhea in the army personals 9 , but yet to see any study that has focused on this important topic.…”

Section: Introductionmentioning

confidence: 99%

Chronic Diarrhea in Soldiers; Facts

Hafeez

Saeed

Qureshi

et al. 2021

PAFMJ

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Objective: To find out the underlying causes of chronic diarrhea in soldiers and how it differs from general population. Study Design: Prospective comparative study. Place and Duration of Study: Combined Military Hospital (CMH) Multan and Pak Emeritus Military Hospital (PEMH) Rawalpindi, from Dec 2017 to Jan 2020. Methodology: All soldiers in active service, having diarrhea more than 4 weeks in study and non-soldiers of the same age were included in the control group. There were inquired in details about the diarrhea symptoms and investigations carried out accordingly to find out the underlying cause. The two groups were compared to find out any differences. The data were analyzed by SPSS version 22. Results: Seventy one in study and 50 patients in control had their mean ages of 34.61 ± 8.35 and 32.42 ± 10.28 years. Mean duration of symptoms were 18 and 15 months in study and control groups respectively. Irritable Bowel Syndrome (IBS) was more common in both groups i.e. 14 (20%) and 20 (40%) in study and control groups respectively but frequency was more in second one. Seropositive celiac disease 13 (18.5%), seronegative villous atrophy 10 (14%) in study and Inflammatory Bowel Disease IBD 6 (12%) in control group were second most common conditions. Conclusions: Irritable bowel syndrome is common in this age group. Celiac and seronegative villous atrophy is second common conditions in the study group.

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A179 Prevalence of Chronic Diarrhea Amongst Patients Followed in Gastroenterology

Cited by 3 publications

References 0 publications

Impact of gastrointestinal symptoms on quality of life in MEN2

Impact of gastrointestinal symptoms on quality of life in MEN2

Colonoscopy and Histopathologic Features in Chronic Diarrhea Patients at Dr. Hasan Sadikin General Hospital Bandung

Chronic Diarrhea in Soldiers; Facts

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