A180 Mid-Latency Auditory Evoked Potentials (Mlaep) and Intraoperative Wakefulness During General Anesthesia (Ga) With Propofol, Isoflurane and Flunitrazepam/Fentanyl

Schwender, D.; Madler, Ch.; Keller, Ingo; Pöppel, Ernst

doi:10.1097/00000542-199009001-00179

Cited by 3 publications

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“…The AEP variables were related significantly to the level of response and fitted the response more closely than end-expiratory gas concentrations. Furthermore, it has been shown that the preserved MLAEP during general anaesthesia correlates with intraoperative motor signs of wakefulness [14][15][16]. In patients undergoing Caesarean section, MLAEP indicated periods of intraoperative consciousness and correlated well with the postoperative recall of surgical manipulations [17].…”

Section: Discussionmentioning

confidence: 99%

Mid-Latency Auditory Evoked Potentials During Ketamine Anaesthesia in Humans

Schwender

Klasing

Madler

et al. 1993

British Journal of Anaesthesia

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We studied mid-latency auditory evoked potentials (MLAEP) during induction of general anaesthesia with ketamine 2 mg kg-1. MLAEP were recorded before, during and after induction of general anaesthesia on the vertex (positive) and mastoid (negative) positions. Latencies of the peak V, Na, Pa, Nb, P1 and amplitudes Na/Pa, Pa/Nb and Nb/P1 were measured. Fast-Fourier transformation was used to calculate power spectra of the MLAEP. In the awake state, MLAEP had large peak-to-peak amplitudes and a periodic waveform. Peak latencies remained within the normal range. Power spectra indicated high energy in the 30-40 Hz frequency range. After induction of general anaesthesia with ketamine, there was no change in latency of peaks V, Na, Pa, Nb, P1 and no apparent reduction in amplitudes Na/Pa, Pa/Nb and Nb/P1. In the power spectra, frequencies in the range of 30-40 Hz retained high energy. Amplitudes and latencies of MLAEP did not change during induction of general anaesthesia with ketamine. Primary processing of auditory stimuli in the primary auditory cortex seemed to be preserved under ketamine. Suppression of sensory (auditory) information processing must take place at a higher cortical level in a dissociative manner.

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Section: Discussionmentioning

confidence: 99%

Mid-Latency Auditory Evoked Potentials During Ketamine Anaesthesia in Humans

Schwender

Klasing

Madler

et al. 1993

British Journal of Anaesthesia

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“…However, it should be noted that MLAEPs are poorly resistant to benzodiazepines and other sedative drugs and anesthetics, thereby being substantially affected by the administration of these compounds [96][97][98][99][100][101].…”

Section: Figure 4: Mlaeps: Recommended Electrode Placement and Normal...mentioning

confidence: 99%

A Comprehensive Review and Practical Guide of the Applications of Evoked Potentials in Neuroprognostication After Cardiac Arrest

Portell Penadés,

Alvarez

2024

Cureus

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Cardiorespiratory arrest is a very common cause of morbidity and mortality nowadays, and many therapeutic strategies, such as induced coma or targeted temperature management, are used to reduce patient sequelae. However, these procedures can alter a patient's neurological status, making it difficult to obtain useful clinical information for the reliable estimation of neurological prognosis. Therefore, complementary investigations are conducted in the early stages after a cardiac arrest to clarify functional prognosis in comatose cardiac arrest survivors in the first few hours or days.Current practice relies on a multimodal approach, which shows its greatest potential in predicting poor functional prognosis, whereas the data and tools to identify patients with good functional prognosis remain relatively limited in comparison. Therefore, there is considerable interest in investigating alternative biological parameters and advanced imaging technique studies. Among these, somatosensory evoked potentials (SSEPs) remain one of the simplest and most reliable tools.In this article, we discuss the technical principles, advantages, limitations, and prognostic implications of SSEPs in detail. We will also review other types of evoked potentials that can provide useful information but are less commonly used in clinical practice (e.g., visual evoked potentials; short-, medium-, and longlatency auditory evoked potentials; and event-related evoked potentials, such as mismatch negativity or P300).

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“…Spectral analysis of the middle latency evoked response (20-100 ms post-stimulus) reveals that the 30-40 Hz component of the power spectrum is suppressed by propofol in anaesthetic doses. The component is diought to be related to conscious sensory information processing [18][19][20].…”

Section: Previous Investigationsmentioning

confidence: 99%

“…Sedative drugs (fentanyl, midazolam and sufentanil) seem to affect predominantly P3 amplitude, with little effect on latency [12][13][14]. Recent observations correlating Nl and P3 amplitudes with different depths of sufentanil anaesthesia indicate that these Previous work in our laboratory indicated that certain variables of the EEG, particularly log beta power (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), correlate with the presence of amnesia in subjects receiving sedative doses of propofol and midazolam [1,2]. We wished to investigate the relation of memory changes with more complex aspects of the EEG signal, such as event-related potentials (ERP), which are very sensitive to the effects of drugs on the central nervous system [3].…”

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confidence: 93%

The P300 event-related potential during propofol sedation: a possible marker for amnesia? † †Presented in part at the annual meeting of the American Society of Anesthesiologists, New Orleans, LA, October 17-21, 1992

Reinsel

Veselis

Wroński

et al. 1995

British Journal of Anaesthesia

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We have studied the effects of conscious sedation with propofol on long latency components of the auditory event-related potential (ERP) in 10 normal volunteers (aged 21-41 yr) receiving propofol 75 micrograms kg-1 min-1 i.v. We examined the effects of propofol on ERP amplitudes and latencies, and their relationship to delayed recognition performance using a verbal memory test, a selective attention task (button pushing) and serum concentrations of propofol. During infusion of propofol, subjects were mildly sedated, oriented and readily responsive to verbal commands. ERP were recorded from monopolar FZ, CZ and PZ electrodes. We used a standard paradigm requiring selective attention to randomly occurring stimuli associated with a task (button push). The peak-to-peak amplitudes and latencies of the N2 and P3 waves were obtained before and during infusion, and 15, 100 and 170 min after infusion. Propofol produced a 70% decrease in the amplitude of P3 (P < 0.0001) from baseline and a 50% increase in reaction time. The differential response to target compared with non-target stimuli was maintained during infusion for both N2 and P3. Memory performance correlated more strongly with changes in P3 amplitude (r = 0.59) than with serum propofol concentrations (r = -0.07), although this correlation with memory did not reach statistical significance (P = 0.08). We conclude that P3 amplitude was profoundly affected by propofol given in sedative concentrations.

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A180 Mid-Latency Auditory Evoked Potentials (Mlaep) and Intraoperative Wakefulness During General Anesthesia (Ga) With Propofol, Isoflurane and Flunitrazepam/Fentanyl

Cited by 3 publications

References 0 publications

Mid-Latency Auditory Evoked Potentials During Ketamine Anaesthesia in Humans

Mid-Latency Auditory Evoked Potentials During Ketamine Anaesthesia in Humans

A Comprehensive Review and Practical Guide of the Applications of Evoked Potentials in Neuroprognostication After Cardiac Arrest

The P300 event-related potential during propofol sedation: a possible marker for amnesia? † †Presented in part at the annual meeting of the American Society of Anesthesiologists, New Orleans, LA, October 17-21, 1992

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