A21 Fermentable Carbohydrate-Microbiome Interactions in a Mouse Model of Ibs

Palma, Giada De; Reed, David E.; Shimbori, Chiko; Pigrau, Marc; Lü, Jun; Louis-Auguste, Marc Philippe; Zhang, Y; Yu, Yang; Jiménez-Vargas, Nestor N.; Sessenwein, Jessica; Lopez, Cintya D. Lopez; Polanco, Josue O. Jaramillo; Verdú, Elena F.; Collins, Stephen M.; Madsen, Karen; Lomax, Alan E.; Beyak, Michael; Vanner, S; Berčík, Přemysl

doi:10.1093/jcag/gwy009.021

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, diet is probably one predictor for the development, frequency, and severity of abdominal pain as it is now evident that diet greatly impacts the microbiome and leads to microbial shifts [65]. The study of De Palma et al [66] showed that a highly fermentable diet leads to altered microbiome compositions. This has been demonstrated in mice that were colonized with fecal microbiota from IBS patients with high urinary histamine.…”

Section: Discussionmentioning

confidence: 99%

Mast Cells in Irritable Bowel Syndrome: A Systematic Review

Krammer

Sowa

Lorentz

2019

JGLD

View full text Add to dashboard Cite

Background and Aims: As mast cells (MC) serve as a link between mucosal immune activity and the nervous system, it is likely they also play a role in the pathogenesis of irritable bowel syndrome (IBS). This connection might be an important factor in the development of IBS-related symptoms. Method: This overview comprises 36 case-control studies published from 2000 to 2018 that investigated MC in bowel biopsies of IBS patients and controls. The studies were selected from PubMed, EMBASE, Central, SemanticScholar by an electronic search, performed using RISMed R package. Results: Significantly increased mucosal MC counts/or density in IBS patients compared to controls was observed in 30 studies. Five studies reported no differences and only one of the studies found a decreased amount of MC in an IBS patient. Furthermore, 15 studies made a statement regarding the correlation between the amount of MC and IBS associated symptoms. A significant positive correlation between MC count and IBS-associated symptoms was found in six investigations. A negative correlation was not reported. Conclusion: The results support the idea that MC are involved in IBS pathophysiology as key players in the interplay between psychological factors and the frequency and severity of IBS symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%