A635 Effect of Hypertonic Saline Resuscitation on Myocardial Performance in a Hemorrhagic Shock Model

Mathru, M.; Rooney, Michael W.; Vengurlekar, S.; Hirsch, Leroy J.; Rao, T. K.

doi:10.1097/00000542-199009001-00633

Anesthesiology

1990

DOI: 10.1097/00000542-199009001-00633

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A635 Effect of Hypertonic Saline Resuscitation on Myocardial Performance in a Hemorrhagic Shock Model

M. Mathru¹,

Michael W. Rooney²,

S. Vengurlekar³

et al.

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1992

1994

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“…This phenomenon is manifest clinically by a transient but significant decrease in packed cell volume and serum total protein content. The hyperosmality of hypertonic solutions also induces an increase in myocardial contractility leading to improved cardiac performance (Baue et al, 1967;Wildenthal et al, 1969a;Mathru et al, 1990). On the other hand myocardial dysfunction can occur if the plasma osmolality reaches extremely high levels (over 400 mOsm.1-1) (Wildenthal et 12 al., 1969a,b).…”

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confidence: 99%

The value of 7.2% hypertonic saline solution in anaesthesia and intensive care: myth or fact?

Gasthuys

1994

Journal of Veterinary Anaesthesia

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mentioning

confidence: 99%

The value of 7.2% hypertonic saline solution in anaesthesia and intensive care: myth or fact?

Gasthuys

1994

Journal of Veterinary Anaesthesia

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Influence of Hypertonic Saline Solution 7.2% on Different Hematological Parameters in Awake and Anaesthetized Ponies

Gasthuys

Messeman²,

Moor³

1992

Journal of Veterinary Medicine Series A

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Summary The influence of hypertonic NaCl 7.2 % infusion (4 ml/kg of body weight [BWT]) on plasma (PV) and blood (BV) volumes, sodium (Na), chloride (Cl), potassium (K) plasma concentrations, osmolality (Osm), total protein content (TP), packed cell volume (PCV) and red blood cell count (RBC) was studied in five standing and anaesthetized ponies (standard halothane anaesthesia). Arterial blood gases were followed in the anaesthetized ponies. Isotonic NaCl 0.9% (4 ml/kg of BWT) was used as a placebo in the standing ponies. Isotonic solution in the standing ponies induced few changes: only small decreases in K, TP, PCV and RBC were observed. Na, Cl and Osm increased significantly after the NaCl 7.2 % infusions in the standing and anaesthetized ponies. Significant decreases in PCV, RBC and TP after the administration of hypertonic solutions were determined and were in both groups clear indications of an occurring hemodilution although no significant increase in PV and BV could be demonstrated. An increase in diuresis characterized by numerous micturations was observed in the standing ponies and during the recovery period after anaesthesia. Apparently, the occurring fluid shift towards the intravascular compartment was partly compensated by an increase in diuresis. The decreases in PCV, RBC and TP were less severe in the anaesthetized ponies compared to the changes observed in the standing ponies. Stress responses during anaesthesia might explain this finding. K increased abnormally at the end of anaesthesia, probably due to minimal muscle damage induced by the dorsal recumbent position. Arterial blood gases did not change after the administration of NaCl 7.2 % solution during anaesthesia. No specific clinical side‐effects related to the use of hypertonic solution could be observed in the standing and anaesthetized ponies. Further studies are necessary to investigate the effects of hypertonic NaCl solution in horses with a disturbed fluid balance (hypovolemia).

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Cardiovascular effects of 7.2% hypertonic saline solution in halothane anaesthetized ponies

Gasthuys

Messeman

Moor

1994

Journal of Veterinary Anaesthesia

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A635 Effect of Hypertonic Saline Resuscitation on Myocardial Performance in a Hemorrhagic Shock Model

Cited by 3 publications

References 0 publications

The value of 7.2% hypertonic saline solution in anaesthesia and intensive care: myth or fact?

The value of 7.2% hypertonic saline solution in anaesthesia and intensive care: myth or fact?

Influence of Hypertonic Saline Solution 7.2% on Different Hematological Parameters in Awake and Anaesthetized Ponies

Cardiovascular effects of 7.2% hypertonic saline solution in halothane anaesthetized ponies

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