2021
DOI: 10.36721/pjps.2021.34.2.sup.773-779.1
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Abstract: Four series of tetrahydro-2H-1,3,5-thiadiazine thione derivatives were screened for their in vitro antiproliferative activities against two human cancerous PC3 and HeLa cell lines. The cytotoxicity of all the compounds (series A-D) was also determined on mammalian mouse fibroblast 3T3 cells. Most of the compounds showed significant anticancer potential against both cancer cell lines within the range of IC 50 = 6.4-29.9 and 2.4-23.8 M respectively when compared with standard doxorubicin (IC 50 = 0.3 M). All c… Show more

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