AACR Cancer Progress Report 2015

Baselga, José; Bhardwaj, Nina; Cantley, Lewis C.; DeMatteo, Ronald P.; DuBois, Raymond N.; Foti, Margaret; Gapstur, Susan M.; Hahn, William C.; Helman, Lee J.; Jensen, Roy A.; Paskett, Electra D.; Lawrence, Theodore S.; Lutzker, Stuart; Szabó, Éva

doi:10.1158/1078-0432.ccr-15-1846

Cited by 40 publications

(28 citation statements)

References 124 publications

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“…In general, regarding the non-specific nature of cancer treatments, both healthy and diseased cells are often damaged, causing severe side effects in patients. Thus, drug delivery vectors have become one of the most promising applications of NPs in the biomedical field with the aim to directly target cancer cells and attenuate side effects [84,85]. Due to PDA's optimal characteristics (i.e., biocompatibility, versatility, and biodegradation), the material is currently used extensively for drug targeting.…”

Section: Biomedical Applications Of Pda Coatingsmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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Biological structures have emerged through millennia of evolution, and nature has fine-tuned the material properties in order to optimise the structure-function relationship. Following this paradigm, polydopamine (PDA), which was found to be crucial for the adhesion of mussels to wet surfaces, was hence initially introduced as a coating substance to increase the chemical reactivity and surface adhesion properties. Structurally, polydopamine is very similar to melanin, which is a pigment of human skin responsible for the protection of underlying skin layers by efficiently absorbing light with potentially harmful wavelengths. Recent findings have shown the subsequent release of the energy (in the form of heat) upon light excitation, presenting it as an ideal candidate for photothermal applications. Thus, polydopamine can both be used to (i) coat nanoparticle surfaces and to (ii) form capsules and ultra-small (nano)particles/nanocomposites while retaining bulk characteristics (i.e., biocompatibility, stability under UV irradiation, heat conversion, and activity during photoacoustic imaging). Due to the aforementioned properties, polydopamine-based materials have since been tested in adhesive and in energy-related as well as in a range of medical applications such as for tumour ablation, imaging, and drug delivery. In this review, we focus upon how different forms of the material can be synthesised and the use of polydopamine in biological and biomedical applications. platform is highlighted ( Figure 1A). Then, theoretical and experimental proof of the chemical formation of polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applications are envisaged. Materials 2019, 12, x FOR PEER REVIEW 2 of 22polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applicatio...

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Section: Biomedical Applications Of Pda Coatingsmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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“…Computer models in the pharmaceutical industry is used to discover new drugs, to optimize of chemical processes and to design clinical trials. Accurate computational estimation of the responses to the treatments and clinical profiles of administration is of great importance for patients [14][15][16][17][18][19]. Also, it is very useful to help clinicians decide on the most effective and least toxic treatment available options, and is significant for researchers to selecte for in vitro and in vivo studies [20][21][22].…”

Section: Computational Models For Radiopharmaceuticalsmentioning

confidence: 99%

Computational Study of Radiopharmaceuticals

Demir¹,

Özgenç²,

Ekinci³

et al. 2019

Molecular Docking and Molecular Dynamics

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Radiopharmaceuticals contain radionuclides and pharmaceuticals. Research on radiopharmaceuticals has been increasing in recent years by increasing the importance of early diagnosis in diseases. It is generally accepted that investigation and development of new radiopharmaceuticals are time and resource consuming. Computational methods have provided exciting contributions to pharmaceutical research and development. The need for designing new radiopharmaceutical drugs enhances the importance of computational programs. At this point, the structure, chemical, physical and physicochemical properties of molecules should be predicted/evaluated by using computational methods. While these methods obtain useful estimates, they make it easier for researchers and clinicians to make the right choices. Also, by providing accurate and effective results, they contribute to reduce the cost of research and can be used to simulate complex biochemical situations before research helping us to avoid harmful effects of drugs. In this study, authors emphasis about radiopharmaceuticals and the computational tools related to the development of new radiopharmaceuticals.

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“…Interaction of H1, H2 and R2 with DNA Figure 5A and 5B, respectively. The binding abilities of H1 and H2 were assessed applying equation (1) [38,39]:…”

Section: Solid-state Structuresmentioning

confidence: 99%

“…The DNA-binding abilities of R2 were assessed by UV-Vis and fluorescence spectroscopy. The absorption data illustrated in Figure S7A were used to determine the intrinsic binding constants K b , applying equation (1). The K b value of 15.3 ± 0.07 × 10 5 M −1 (log K b = 6.18) indicates that the DNA-binding affinity of R2 is clearly higher than those of H1 and H2.…”

Section: (2)mentioning

confidence: 99%

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Antiproliferative properties of iron supramolecular cylinders

Brissos¹,

Korrodi‐Gregório²,

Pérez-Tomás³

et al. 2018

Chem.Sq.

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The use of metallohelicates as potential antiproliferative agents is mostly exemplified by one sole family of supramolecular compounds that is based on bis-iminopyridine ligands. In the present investigation, two other types of metallocylinders have been selected and their potential DNA-binding and cytotoxic properties have been investigated. Hence, two new neutral iron(III) metallosupramolecular compounds have been prepared from bis-β-diketone ligands, and a known cationic iron(II) helicate from bis-pyrazole ligands has been used for comparison purposes. DNA-interaction experiments and cell studies reveal remarkable biological properties for one of the neutral iron cylinders and the positively charged, pyrazole-based helicate, as illustrated by their antiproliferative behaviours, which are far better than those of two well-known compounds, i.e. the most studied metallohelicate in the field and cisplatin.

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AACR Cancer Progress Report 2015

Cited by 40 publications

References 124 publications

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

Computational Study of Radiopharmaceuticals

Antiproliferative properties of iron supramolecular cylinders

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