Nowadays with heart diseases most of peoples are dying lock process to find problem agile fashion in remote areas. In this research help to peoples who are staying remote also to find problem in heart on which location and how much problem to near and finally gives best analysis methodology for automated analysis for MultiSlice CT Angiogram images. Multi slice CT scanner is used to identify heart disease. Multi-detector CT is considered convenient and reliable non-invasive imaging modality for assessment of human angiogram 3D images. Automatic hart segmentation from Computed Tomography (CT) is highly demanded. Accurate hart segmentation is a crucial for computer-aided heart disease diagnosis and treatment planning. After segmentation and future extraction then identify whether the patient angiogram waveform has disease or not. For that, Support Vector Machine method is used to confirm the presence of disease. Neural Networks can solve different types of nonlinear problems in image classification and retrieval process. After that majorly focus on research learning methodologies for improve performance of the Multi Slice CT Angiogram images. So, in this research is summarizing the problem with liner of RBF neural network, Non-Liner SVM and RBF NN with liner and non-liner. Final, RBF NN with liner and non-liner provided more value and proved as best compare with other existing methodologies. This methodology consumes less time for both learning as well as testing comparatively than any other methods like back propagation. This issue drastically improves the estimation efficiency and accuracy for real time 128, 256 slices CT scan angiogram images.