2024
DOI: 10.1002/advs.202402166
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AAV‐mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives

Liyan Zhang,
Fangzhi Tan,
Jieyu Qi
et al.

Abstract: Hereditary deafness is the most prevalent sensory deficit disorder, with over 100 identified deafness‐related genes. Clinical treatment options are currently limited to external devices like hearing aids and cochlear implants. Gene therapy has shown promising results in various genetic disorders and has emerged as a potential treatment for hereditary deafness. It has successfully restored hearing function in >20 types of genetic deafness model mice and can almost completely cure patients with hereditary aut… Show more

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