AAV-mediated siRNA against TRPV1 reduces nociception in a rat model of bone cancer pain

Zhang, Shuangli; Zhao, Jun; Meng, Qinggang

doi:10.1080/01616412.2019.1639317

Cited by 21 publications

(15 citation statements)

References 33 publications

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“…The BCP includes not only the tumor itself but also the inflammatory reaction, peripheral sensitization and central sensitization. 32 Role of astrocytes and microglia during pain pathogenesis has been implicated in several studies. [33][34][35][36][37] Inflammatory activation of astrocytes and microglia leaded to proinflammatory cytokines expression and neuronal damage.…”

Section: Discussionmentioning

confidence: 99%

Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation

Luo

Jin

et al. 2020

Mol Pain

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Background: Bone cancer pain is common in patients with advanced cancers as tumor metastasizes to bone. The inefficient clinical treatment severely reduces quality of life of bone cancer pain patients. During the pain status, activated spinal astrocytes and microglia release various inflammatory cytokines, resulting in spinal inflammation and the development of neuron sensitization. Scorpion is the dry body of Buthus martensii Karsch and is often used for various pain management in clinical practice. However, its function on bone cancer pain is unclear. Methods: We investigated the effects of intragastric administration of scorpion on bone cancer pain induced by left tibial cavity injection of Walker 256 cells. Nociceptive behavior was measured using the von Frey filaments test and the spontaneous ambulatory pain score. The bone destruction was assessed by tibial radiographs. Expression of spinal cord astrocyte marker glial fibrillary acidic protein and microglial marker Iba1 was monitored by Western blot assay and immunofluorescence. Tumor necrosis factor-alpha (TNF-a), interleukin (IL)-6, and IL-1b was detected by real-time polymerase chain reaction. The proliferation of Walker 256 cells was evaluated by CCK8 assay. Results: Intragastric administration of scorpion reduced bone cancer pain behavior and relieved bone destruction, accompanied by decreased expression of spinal glial fibrillary acidic protein and Iba1 protein level and TNF-a, IL-6, and IL-1b mRNA level. Besides, scorpion inhibited proliferation of Walker 256 cells in a dose-and time-dependent manner. Conclusion: Our results demonstrate that scorpion produces an analgesic effect in a rat model of bone cancer pain via inhibiting bone destruction and activation of spinal cord astrocytes and microglia.

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Section: Discussionmentioning

confidence: 99%

Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation

Luo

Jin

et al. 2020

Mol Pain

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“…The AAV could infect nondividing cells and integrate its genes engineered by researchers into the specific site of human genes to express proteins for killing cancer cells. So far, the AAV has been employed to treat many types of cancers, 162 such as liver cancer, 163 colorectal cancer, 164 lung cancer, 165 glioblastoma, 166–168 breast cancer, 169 leukemia, 170 mesothelioma, 171 pancreatic cancer mice, 172 cervical cancer, 173 ovarian cancer, 174 melanoma cells,, 175 and bone cancer 176 …”

Section: Virus Nanoparticlesmentioning

confidence: 99%

“…So far, the AAV has been employed to treat many types of cancers, 162 such as liver cancer, 163 colorectal cancer, 164 lung cancer, 165 glioblastoma, [166][167][168] breast cancer, 169 leukemia, 170 mesothelioma, 171 pancreatic cancer mice, 172 cervical cancer, 173 ovarian cancer, 174 melanoma cells" 175 and bone cancer. 176…”

Section: Human Virusesmentioning

confidence: 99%

Bionanoparticles in cancer imaging, diagnosis, and treatment

Bao

Yang

et al. 2022

VIEW

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Biological molecules such as DNA, proteins, and lipids can be assembled into naturally existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages), plant viruses, nucleic acid nanoparticles (e.g., DNA origami), protein nanoparticles, and exosomes. These bionanoparticles have their own distinct properties (including compositions, structures, shapes, and functions), laying the foundation for their unique applications as probes for cancer imaging, as detectors for cancer diagnosis, or as therapeutics for cancer therapy. To highlight how the distinct properties of different bionanoparticles can be explored in cancer nanotheranostics, this review critically analyzed the use of bionanoparticles in cancer imaging, diagnosis, and treatment. Specifically, for each of these representative bionanoparticles, we describe its unique properties that render it powerful in cancer theranostics compared with synthetic inorganic nanoparticles. We also summarize how to genetically or chemically modify or redesign the bionanoparticles so that they gain new functions desired for cancer theranostics, such as tumor‐seeking or tumor‐destructive capabilities. Finally, we discussed the challenges in this exciting field. The bionanoparticles covered in this review represent different biomolecular assemblies with unique theranostic applications, showcasing the power of bionanoparticles in disease diagnosis and treatment.

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“…Genetic manipulations to knock out or silence the TRPV1 expression cause alleviation of mechanical allodynia and thermal hyperalgesia in tumor inoculated animals. This antinociceptive activity was attributed to the suppression of the class-I histone deacetylase enzymes as well as TNFα levels in the spinal cord …”

Section: Peripheral and Central Mechanisms Encoding Bone Cancer Painmentioning

confidence: 99%

“…This antinociceptive activity was attributed to the suppression of the class-I histone deacetylase enzymes as well as TNFα levels in the spinal cord. 13 ASICs are a member of the degenerin/epithelial Na + channel superfamily which gets stimulated via protons present in the extracellular environment. 14 ASIC3 in the sensory terminal endings is activated by acidic pH (6.5−7.0) and initiates pain transduction.…”

Section: Peripheral and Central Mechanismsmentioning

confidence: 99%

Multifarious Targets and Recent Developments in the Therapeutics for the Management of Bone Cancer Pain

Gadepalli

Akhilesh

Uniyal

et al. 2021

ACS Chem. Neurosci.

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Bone cancer pain (BCP) is a distinct pain state showing characteristics of both neuropathic and inflammatory pain. On average, almost 46% of cancer patients exhibit BCP with numbers flaring up to as high as 76% for terminally ill patients. Patients suffering from BCP experience a compromised quality of life, and the unavailability of effective therapeutics makes this a more devastating condition. In every individual cancer patient, the pain is driven by different mechanisms at different sites. The mechanisms behind the manifestation of BCP are very complex and poorly understood, which creates a substantial barrier to drug development. Nevertheless, some of the key mechanisms involved have been identified and are being explored further to develop targeted molecules. Developing a multitarget approach might be beneficial in this case as the underlying mechanism is not fixed and usually a number of these pathways are simultaneously dysregulated. In this review, we have discussed the role of recently identified novel modulators and mechanisms involved in the development of BCP. They include ion channels and receptors involved in sensing alteration of temperature and acidic microenvironment, immune system activation, sodium channels, endothelins, proteaseactivated receptors, neurotrophins, motor proteins mediated trafficking of glutamate receptor, and some bone-specific mechanisms. Apart from this, we have also discussed some of the novel approaches under preclinical and clinical development for the treatment of bone cancer pain.

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AAV-mediated siRNA against TRPV1 reduces nociception in a rat model of bone cancer pain

Cited by 21 publications

References 33 publications

Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation

Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation

Bionanoparticles in cancer imaging, diagnosis, and treatment

Multifarious Targets and Recent Developments in the Therapeutics for the Management of Bone Cancer Pain

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