Ab initio study regarding the evaluation of the antioxidant character of cyanidin, delphinidin and malvidin

Pop, Raluca; Ștefănuț, Mariana Nela; Căta, Adina; Tănasie, Cristian; Medeleanu, Mihai

doi:10.2478/s11532-011-0128-1

Cited by 27 publications

(18 citation statements)

References 24 publications

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“…As one of the commonest and most predominant anthocyanins that exist in red wines and black rice, malvidin is found to exhibit an important antioxidant and anti‐inflammatory activity 12,13 . It has been revealed in an in vitro study that malvidin has a strong antioxidant ability, along with other crucial properties for free radicals scavenging 14 . A study by Huang et al on endothelial cells suggests that blubbery (rich in malvidin) has a reducing effect on ROS, xanthine oxidase‐1, and an increasing impact on the superoxide dismutase (SOD) levels 5 .…”

Section: Introductionmentioning

confidence: 99%

Malvidin prevents lipopolysaccharide‐induced oxidative stress and inflammation in human peripheral blood mononuclear cells

et al. 2020

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It is indicated that malvidin has anti‐inflammatory and antioxidant effects on various cells, although the function of malvidin in preventing inflammatory reactions caused by lipopolysaccharide (LPS) in peripheral blood mononuclear cells (PBMCs) is still not known. The objective of this study was to examine the impact of malvidin on inflammatory responses and oxidative stress in PBMCs as caused by LPS. The present findings showed that LPS significantly increased the expression of IL‐6, TNF‐α, IL‐1β, and COX‐2 mRNA and protein release from PBMCs 22 hr after treatments. It was also revealed that increased levels in cytokine expression coincided with increased phosphorylation of JNK, P65‐NF‐κB, and IKKα/IKKβ. Also, the expression of IL‐6, TNF‐α, IL‐1β, and COX‐2 mRNA induced by LPS as well as secretion of protein in PBMC has been significantly decreased by pretreatment of malvidin. Importantly, pretreatment of the cells with malvidin completely abrogated the phosphorylation of P65‐NF‐κB, JNK, and IKKα/IKKβ in LPS treated cells. Malvidin protection against LPS‐induced inflammation was coupled with a decline in the levels of nitric oxide metabolite and malondialdehyde, along with an increase in the ferric reducing antioxidant power, total thiol activity, and also superoxide dismutase and glutathione peroxidase activity. In accordance with this finding, malvidin may represent a promising therapeutic agent for the prevention of inflammation in PBMCs.

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Section: Introductionmentioning

confidence: 99%

Malvidin prevents lipopolysaccharide‐induced oxidative stress and inflammation in human peripheral blood mononuclear cells

et al. 2020

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“…Malvidin possesses great antioxidant capacity with excellent free radical scavenging properties in vitro [ 7 ]. Malvidin exhibits antihypertensive activity by inhibiting angiotensin I-converting enzyme and anti-inflammatory effect by blocking NF- κ B pathway [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells

Huang

Zhu

et al. 2016

Oxidative Medicine and Cellular Longevity

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The objective of this research was to survey the antioxidant functional role of the main anthocyanins of blueberries in endothelial cells. Changes on the reactive oxygen species (ROS), xanthine oxidase-1 (XO-1), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in cells of malvidin and the two glycosides were investigated. The results showed that these anthocyanins decreased the levels of ROS and XO-1 but increased the levels of SOD and HO-1. Glycosides improved the antioxidant capacity of malvidin to a great extent. The changes in the antioxidant properties of malvidin-3-glucoside were more pronounced than malvidin-3-galactoside. Variation in levels of malvidin-3-glucoside and malvidin-3-galactoside had a significant impact on antioxidant properties to different extents. It indicates that blueberries are a good resource of anthocyanins, which can protect cells from oxidative deterioration and use blueberry as a potential functional food to prevent diseases related to oxidative stress.

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“…CAJY exhibited potent anti-oxidant activities involving DPPH radical scavenging, GSH enhanced activity, and reduced cellular ROS production. A theoretical study evaluated the anti-oxidant character of three common anthocyanidins (cyanidin, delphinidin, and malvidin) 35) according to different parameters (bond dissociation enthalpy, ionization potential, proton affinity, and electron transfer enthalpy) and the atomic charges corresponding to the O atoms of the hydroxyl groups. In addition, the anti-oxidant effect of anthocyanins involves free radical scavenging by OH groups.…”

Section: Discussionmentioning

confidence: 99%

<i>p</i>-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of <i>Solanum tuberosum</i> Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

Lee

Shin

et al. 2017

Biological & Pharmaceutical Bulletin

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Previously, we first reported the identification of four p-coumaroyl anthocyanins (petanin, peonanin, malvanin, and pelanin) from the tuber epidermis of colored potato (Solanum tuberosum L. cv JAYOUNG). In this study, we investigated the anti-oxidative and anti-inflammatory effects of a mixture of peonanin, malvanin, and pelanin (10 : 3 : 3; CAJY). CAJY displayed considerable radical scavenging capacity of 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), increased mRNA levels of the catalytic and modulatory subunit of glutamate cysteine ligase, and subsequent cellular glutathione content. These increases preceded the inhibition of lipopolysaccharide (LPS)-induced intracellular reactive oxygen species (ROS) production. CAJY inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a concentration-dependent manner at the protein, mRNA, and promoter activity levels. These inhibitions caused attendant decreases in the production of prostaglandin E 2 (PGE 2 ). CAJY suppressed the production and mRNA expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Molecular data revealed that CAJY inhibited the transcriptional activity and translocation of nuclear factor κB (NF-κB) and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT3. Taken together, these results suggest that the anthocyanin mixture exerts anti-inflammatory effects in macrophages, at least in part by reducing ROS production and inactivating NF-κB and STAT 1/3. Key words anthocyanin; macrophage; antioxidant; anti-inflammatory; nuclear factor κB; signal transducer and activator of transcription Reactive oxygen species (ROS) are important in various biological processes at the levels of gene expression, protein translation, post-translational modification, and protein interactions.1) Cell-derived ROS independently or cooperatively regulate cellular signaling in response to environmental cues. 1)A sustained pro-inflammatory state characterized by excessive ROS production is the common aspect in the development, progression, and complication of obesity, infections, cardiovascular and neurodegenerative diseases, and cancer.2-4) The shift in the balance between oxidants and anti-oxidants in favor of oxidants is termed oxidative stress. This stress contributes to many pathological conditions.Aerobic organisms have integrated anti-oxidant systems, which include enzymatic and non-enzymatic antioxidants, that are usually effective in blocking harmful effects of ROS. 5)Anti-oxidant defense systems comprise glutathione (GSH) and its synthesis, phase II detoxifying enzymes, and ROS inactivating enzymes, which play key roles in protecting cells upon oxidative damage. 6) GSH effectively protects cells from various oxidative stresses caused by scavenging free radicals, suppression of lipid peroxidation, and removal of hydrogen peroxides in cells.7) Glutamate cysteine ligase (GCL) is the rate-limiting enzyme for de novo GSH synthesis and comprises a heterodimer formed of a catalytic subunit (GCLC) and a modulator...

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Ab initio study regarding the evaluation of the antioxidant character of cyanidin, delphinidin and malvidin

Cited by 27 publications

References 24 publications

Malvidin prevents lipopolysaccharide‐induced oxidative stress and inflammation in human peripheral blood mononuclear cells

Malvidin prevents lipopolysaccharide‐induced oxidative stress and inflammation in human peripheral blood mononuclear cells

Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells

<i>p</i>-Coumaroyl Anthocyanin Mixture Isolated from Tuber Epidermis of <i>Solanum tuberosum</i> Attenuates Reactive Oxygen Species and Pro-inflammatory Mediators by Suppressing NF-κB and STAT1/3 Signaling in LPS-Induced RAW264.7 Macrophages

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