2022
DOI: 10.1136/annrheumdis-2022-eular.2832
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Ab0028 il-2 Deprived Phenotype of Foxp3+ Regulatory T Cells and Phenotypic Alterations Conventional Cd4+ T Cells in Patients With Inflammatory Myopathies and Primary Sjogren´s Syndrome

Abstract: BackgroundA defect in regulatory T cell (Treg) homeostasis due to an acquired deficiency of interleukin-2 (IL-2) plays an important role in the pathogenesis of systemic lupus erythematosus (SLE).1,2 However, it is still unclear whether a defect in the Treg-IL-2 axis is also involved in other connective tissue disease such as inflammatory myopathies or primary Sjogren´s syndrome (pSS).ObjectivesThe aim of our study was to investigate whether Treg from patients with poly- and dermatomyositis (PM/DM) and pSS disp… Show more

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