Cartilage, Synovium and Bone 2018
DOI: 10.1136/annrheumdis-2018-eular.4846
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AB0087 Synovial tissue macrophages polarisation (M1, M2) in patients with undifferentiated arthritismeeting diagnostic criteria for rheumatoid arthritis or psoriatic arthritis along the follow up

Abstract: BackgroundUndifferentiated arthritis (UA) is defined as an inflammatory oligo-or polyarthritis that does not fulfil criteria for a definitive diagnosis. Earlier diagnosis would permits a better functional prognosis. Synovial tissue (ST) macrophages have been associated with disease activity, radiographic erosion and response to therapy in RA. Furthermore, it has been reported that M1 polarised macrophages predominate in RA synovitis, whereas M2 predominate in SpA synovitis.1 ObjectivesTo analyse polarised macr… Show more

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“…The proteins encoded by several of the GM-CSF-associated gene markers have also been detected in macrophages from active RA synovial tissue, including activin A, MMP12 and CCR2 (29). We analyzed the expression of markers of GM-CSF derived macrophages (INHBA, MMP12, and TNFα) and M-CSF derived macrophages (CD209) on CD163+ macrophages, and found a similar expression of GM-CSF- and M-CSF-associated markers in synovial tissue of RA and PsA patients (30) (Figure 1B). These results support the presence of similar GM-CSF and M-CSF skewed macrophages in RA and PsA synovitis.…”
Section: Synovial Tissue Features In Psa Synovitismentioning
confidence: 80%
“…The proteins encoded by several of the GM-CSF-associated gene markers have also been detected in macrophages from active RA synovial tissue, including activin A, MMP12 and CCR2 (29). We analyzed the expression of markers of GM-CSF derived macrophages (INHBA, MMP12, and TNFα) and M-CSF derived macrophages (CD209) on CD163+ macrophages, and found a similar expression of GM-CSF- and M-CSF-associated markers in synovial tissue of RA and PsA patients (30) (Figure 1B). These results support the presence of similar GM-CSF and M-CSF skewed macrophages in RA and PsA synovitis.…”
Section: Synovial Tissue Features In Psa Synovitismentioning
confidence: 80%
“…In nonspecific, or innate, immunity, local microenvironmental changes and different stimuli will lead to different macrophage responses, resulting in distinct M1 and M2 functional phenotypes [ 23 ]. The degree and type of synovial tissue macrophage polarization in patients should probably be considered a diagnostic marker of RA [ 24 ]. In RA progression, macrophages function through polarizing into the proinflammatory ‘M1' phenotype, leading to the production of toxic effector molecules such as reactive oxygen species and nitric oxide, and proinflammatory cytokines, which induce cartilage and bone erosion.…”
Section: Discussionmentioning
confidence: 99%