Ab0195 platelet to Lymphocyte Ratio: A Biomarker of Structural Damage in Rheumatoid Arthritis

Abstract

BackgroundA regular monitoring of structural damage in patients with rheumatoid arthritis (RA) is necessary to adjust the treatment. However, the rhythmicity of new radiographs to assess the structural damage is not codified. There is no biomarker able to reflect structural damage.ObjectivesOur study aimed to assess the relationship between the modified Sharp score and the platelet to lymphocyte ratio.MethodsWe performed a cross-sectional study including 53 patients with RA. A cell blood count was performed for each patient, and PLR was calculated. Modified Sharp score and its components (erosion score and joint space narrowing score) were evaluated using the radiograph of hands and feet.Statistical analysis was performed using SPSS (Statistical Package for Social Sciences).ResultsOf the 53 patients, 39 were female (Sex Ratio: 2.8). The mean age was 53.9 ± 12.7 years. The mean age of the onset of the disease was 43.8±13.5 years. The mean disease duration was 10.1 ± 8.2 years. The mean DAS 28-ESR score was 4.64 ± 1.23.The mean value of PLR was 161.62 ± 86.59. The mean modified Sharp score was 46.33 ± 37.74. Thirty-two percent of patients had a modified Sharp score greater than 50. The mean scores of joint erosion and joint space narrowing were 12.76 ± 15.05 and 33.57 ± 25.80.Modified Sharp score was correlated to the PLR (r: 0.501; p <10-3).Moreover, joint space narrowing score and joint erosion score were correlated to the PLR (r: 0.558; p <10-3 and r: 0.299; p: 0.033, respectively).Patients with a modified Sharp score ≥ 50 had a higher PLR (203.12 ± 101.71 versus 142.33 ± 74.07).As shown in Figure 1, the ability of PLR to distinguish patients with a modified Sharp score ≥ 50 was good with an AUC of 0.704 (p= 0.021) with a cut-off of 130.5 (sensitivity=75%, specificity=65.7%).Figure 1.ROC curve assessing the ability of PLR to distinguish patients with a modified Sharp score ≥ 50ConclusionOur study showed that the modified Sharp score correlated with PLR, which ​​can be useful to distinguish patients with severe structural damage with a cut-off of 130.5. This finding suggests that this ratio is a reliable marker to reflect radiographic joint damage.Disclosure of InterestsNone declared