AB0233 Productivity costs in as. comparison among 3 european countries

Abstract

activity, using an intervention of known efficacy (Infliximab) as external standard. Methods Until now, 12 RA patients (ACR criteria) have been included (1 male), having high or moderate disease activity (DAS28 >3.2); 3 10 patients already had a 6-week follow-up. The intervention consisted of treatment with Infliximab and Methotrexate, which is likely to induce a relatively large improvement after 6 weeks. The RADAI was self-administered 1 week before the first infusion with Infliximab (T0). At the first infusion (T1), the patient filled in the RADAI again and the physician assessed the DAS28.After 6 weeks (T2), the RADAI and the DAS28 were again assessed. For analysis of reliability (T0 and T1) the ICC3,1 and the Limits-of Agreement [4] were used. Responsiveness was studied by judging the change in RADAI at T2 in relation to the Limits-of-Agreement and the DAS28 response criteria. 3 Results The RADAI scores at T0 and T1 were mean (sd) 5.0 (1.7) and 4.8 (1.9). The mean (sd) difference was -0.2 (0.8), (paired t-test, p = 0.41). The ICC3,1 was 0.89 (p < 0.05). The Upper Limit-of-Agreement was at 1.6 and the Lower at -2.0. According to the DAS28 response criteria, 3 patients were classified as having no response at T2, 3 had a moderate and 4 a good response. The change in RADAI did not exceed the Lower Limit-of-Agreement for 4 of the 7 responders. The responders had a median (range) change in RADAI of -2.1 (-0.9 to -8.0), signed rank test, p = 0.02). Conclusion The data collection is ongoing till N = 20. The first results on reliability and responsiveness are promising. However, if the Limits-of-Agreement turn out to be much wider than -1 and +1, the reliability of the RADAI should be improved.

Economic analysis of patient-related effects of an interdisciplinary pain self-management program

“…Chronic pain commonly affects peoples' ability to perform day-to-day activities and limits their capacity to remain in paid employment. [7][8][9][10][11]43,49,56 Patients with chronic pain often also experience poor mental health, 45 such as heightened depression and anxiety symptoms. The costs of chronic pain place a significant public health burden on countries.…”