Ab0266 the Influence of Heredity on Rheumatoid Arthritis: Examining the Distinct Characteristics in Patients With a Family History

Abstract

BACKGROUND:NIL.ObjectivesThe aim of this study was to describe the particularities of patients diagnosed with rheumatoid arthritis (RA) who have a family history of the disease.MethodsIn this retrospective study, a total of patients diagnosed with RA between the years 2011 and 2022 were included. The primary aim of the study was to investigate the relationship between different parameters such as age of disease onset, Disease Activity Score using C-reactive protein(DAS CRP), serological profile, erosive character,extra-articular manifestations, and use of biotherapy. Data were collected from the medical records of the patients, and analyzed using statistical test such chi-squared, Fisher’s exact test and t-test.the level of significance was set at p=0.05.the study design included a thorough data cleaning process.Results:Table 1.RA with Family History (n=21)RA without Family History (n=386)(p)Sex-Ratio66.121.00Young onset RA (%)66.755.30.30Extra-articular manifestations (%)66.746.30.05Serological profile (%)85.787.50.73C-reactive protein (mg/L)22.25 ± 37.2327.87 ± 25.110.487DAS CRP*5.3 ± 1.635.4± 2.50.90Erosions (%)81870.50The use of biological treatment (%)38.139.20.91DAS CRP*: Disease Activity Score using C-reactive proteinThe study included 407 patients with a mean age of 58.86 years ± 12.441, and a sex ratio of 6 (F/M). The median duration of the disease was 14 ± 7.523 years. Erosions were found in 87.2% of patients. Rheumatoid factor (RF) was positive in 85% of patients and anti-citrullinated protein antibodies (ACPA) were positive in 64.9% of patients. The mean DAS 28 score was 5.409± 2.52, the mean CRP was 33.84±35.19, and extra-articular manifestations were found in 46.4% of patients and 39.1% of patients were receiving biological treatment. 21 patients (5.17%) reported a family history of RA. In bivariate analysis, RA patients with a family history had more extra-articular manifestations compared to patients without a family history of the disease (66.7%) versus (46.3%) (p =0.05). No association was found for the other parameters.ConclusionThe results of this study suggest that a family history of RA may be a predictive factor for extra-articular manifestations in patients with the disease. These findings highlight the importance of considering family history when evaluating and treating patients with RA. Further research is needed to confirm these results and to better understand the underlying mechanisms.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.