AB0288 Laboratory markers of inflammation and serum nicotinamide phosphoribosyltransferase level in rheumatoid arthritis patients

Abstract

ObjectivesTo study relationship between serum levels of nicotinamide phosphoribosyltransferase and laboratory markers of inflammation in patients with rheumatoid arthritis (RA).MethodsWe determined nicotinamide phosphoribosyltransferase level in sera of 140 patients with RA (96 women and 44 men) by indirect enzyme-linked immunosorbent assay (RaiBiotech, cat No. EIA-VIS-1). The control group consisted of 20 women and 10 men aged 22 to 55 years without complaints of pain in the joints throughout life. The mean duration of disease was 5.94±0.37 years.ResultsWe divided all RA patients into 2 groups: one group (118 patients) with elevated levels of nicotinamide phosphoribosyltransferase serum (more than 3.9 ng/ml) and second group (22 patients) - with normal range.In each of the two groups, the levels of CRP and ESR were determined.Patients with elevated levels of Nampt had the following laboratory parameters (M±m): ESR – 37.83±1,57, CRP – 56.09±3,73 (rate - less than 5.0 mg/l). The second group had following data: ESR 22.46±0,56, CRP 21,65±1.38. Thus, patients with elevated levels of nicotinamide phosphoribosyltransferase had significantly higher concentrations of ESR and CRP (p<0,001).ConclusionsThere is the relationship between the level of nicotinamide phosphoribosyltransferase serum and laboratory markers of inflammation in RA (CRP and ESR). The data indirectly confirm the hypothesis that increased levels of nicotinamide phosphoribosyltransferase in RA patients is associated with disease activity.Disclosure of InterestNone declared

The role of tissue cytokines in the pathogenesis of rheumatic diseases

“…Адипонектин и Фетуин А относят к негативным белком острой фазы. Их концентрация снижается при росте уровня провоспалительных цитокинов: фактора некроза опухоли-α (ФНО-α), интерлейкина-1 (ИЛ)-1 и ИЛ-6 [5,10].…”