2013
DOI: 10.1136/annrheumdis-2013-eular.2628
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AB0306 Tocilizumab therapy resulted in significantly increased heart rate variability and improved lipid profile in patients with rheumatoid arthritis

Abstract: Background Inflammation plays a crucial role in rheumatoid arthritis (RA) pathogenesis. Tocilizumab (TCZ) is effective therapy in RA. One of the leading causes of death in RA is cardiovascular events (CVE). Impact of TCZ on the development of CVE remains unclear. Heart rate variability (HRV) (as indicator of cardiac autonomic neuropathy (CAN)) and blood lipids are recognized as important and independent risk factors for CVE. Objectives to analyze HRV parameters, blood lipid levels initially and after 6 months… Show more

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Cited by 2 publications
(3 citation statements)
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“…IL-6 concentration remains higher than preoperative one in 24 h after CABG. [19,20] Thus, we confirmed the results of the study according to which IL-6 increases during and just after the EC, which is caused by surgical injury, and decreases on the 3 rd -5 th days after the surgery but further remaining of its increased values is the evidence of significance of systemic inflammatory reaction [21] and can be used for prognosis of course of inpatient period. Authors consider at the high level of MMP-1 in the patients with coronary atherosclerosis is a risk factor of the onset and development of acute coronary syndrome, because MMP-1 contributes to injury to APs, where later clotting occurs.…”
Section: Discussionsupporting
confidence: 85%
“…IL-6 concentration remains higher than preoperative one in 24 h after CABG. [19,20] Thus, we confirmed the results of the study according to which IL-6 increases during and just after the EC, which is caused by surgical injury, and decreases on the 3 rd -5 th days after the surgery but further remaining of its increased values is the evidence of significance of systemic inflammatory reaction [21] and can be used for prognosis of course of inpatient period. Authors consider at the high level of MMP-1 in the patients with coronary atherosclerosis is a risk factor of the onset and development of acute coronary syndrome, because MMP-1 contributes to injury to APs, where later clotting occurs.…”
Section: Discussionsupporting
confidence: 85%
“…Интенсивность болевого синдрома при РА отрицательно, однако обратимо, влияет на активность ПНС (по данным ХМ-ЭКГ). С другой стороны, тяжесть РА (рентгенологическая стадия) коррелирует с необратимым нарушением кардиальной автономной нейрорегуляции [49].…”
Section: кардиальная автономная нейропатия вариабельность ритма сердunclassified
“…Таким образом, эффективная терапия ритуксимабом сопровождается снижением ЧСС и улучшением ВРС [57]. Положительное влияние на ВРС у больных РА отмечено и у тоцилизумаба [49]. Также известно, что низкие парасимпатические показатели ВРС в комбинации с высоким уровнем СНС и индексом напряжения являются предикторами плохого ответа на ингибиторы ФНО α у больных РА [58].…”
Section: кардиальная автономная нейропатия и воспалениеunclassified