AB0482 Evaluation of Current and at The Onset Clinical Manifestations in Systemic Lupus Erythematosus Patients

Abstract

BackgroundSystemic Lupus Erythematosus (SLE) in a multisystemic autoimmune disease that specially affects young women during the second and third decade, and is able to injure different organs and or systems, being the most common one affected the musculoskeletal system.ObjectivesTo analyse the influence of the time of evolution and age of the patient in the current clinical manifestations and the debut of the disease in patients with SLE.MethodsCross-sectional prospective study of SLE patients according to the SLICC-2012 criteria, coming from the Rheumatology Service of Arnau de Vilanova Hospital and La Fe Hospital. All patients had a complete blood-test with autoimmunity markers, and clinical, biometrics and treatment data were also collected from the personal interview and the medical history. Biostatistical analysis was performed using the R software version 3.2.3., using a simple, binomial and logistic lineal regression.ResultsA total of 140 patients were evaluated; of them, (95% were women) with 33.39±13.63 year-old average at the diagnosis time with a 10.05±11.42 year-evolution of SLE. We can find the clinical manifestations at the onset disease on the table.Onset manifestation(%)Onset manifestation(%)Musculoskeletal73.6Sjogren synd.2.9Skin39.3Raynaud's5Kidney5Other27.1Cytopenia7.9We observe statistically significant differences in the musculoskeletal system involvement (P=0.008), and in the presence of vasculitis (P=0.01) in patients with a shorter time of disease evolution. There is also a direct relationship between cardiovascular (P=0.002) and renal (P=0.03) affection in younger patients. Finally, cytopenias are correlated both in young patients (P=0.0009) as well as with a shorter time of evolution (P=0.02).ConclusionsWe observe a concordance between our SLE series and those already described at the literature, where renal involvement occurs at younger ages, and the musculoskeletal system involvement occurs early in disease or even as the onset symptom.Disclosure of InterestNone declared