AB0585 A lupus low disease activity state is associated with reduced flare, lower organ damage accrual, and better quality of life in patients with systemic lupus erythematosus

Abstract

ObjectivesTo identify the potential predictors of a lupus low disease activity state (LLDAS), and the relationship between LLDAS and disease flare, organ damage, and quality of life in Korean patients with systemic lupus erythematosus (SLE).MethodsThe study followed 181 SLE patients from a single centre for three years. LLDAS was defined as follows:1 SLE Disease Activity Index (SLEDAI)−2K≤4, with no activity in major organ systems;2 no new lupus disease activity compared with the previous assessment;3 SLEDAI Physician Global Assessment≤1;4 a current prednisolone (or equivalent) dose ≤7.5 mg daily; and5 well-tolerated standard maintenance doses of immunosuppressive drugs. We assessed data annually and divided 4 groups according to the number of LLDAS; LLDAS=0, 1, 2, and 3. Univariate and multivariate analyses were performed to identify predictors of LLDAS.ResultsOf the 181 patients, 16.0% attained LLDAS on three consecutive years. Each group shows as follows; no LLDAS (n=30), LLDAS=1 (n=60), LLDAS=2 (n=62), and LLDAS=3 (n=29). The patients who had higher number of LLDAS had shorter duration of symptoms, lower anti-histone antibody positivity, lower cumulative prescribed dose of prednisolone at baseline, lower mean PGA, lower mean SLEDAI, lower mean Mental Component Summary in SF-36, lower change in SLICC/ACR damage index, and a lower frequency of flare. In the multivariate analysis, LLDAS was significantly associated with lower mean PGA (OR=0.671, 95% CI: 0.112–0.989, p=0.019) and a reduced risk of flare after adjusting for confounders (OR=0.012, 95% CI: 0.001–0.448, p=0.017).ConclusionsAttaining LLDAS was associated with an improved outcome, as represented by a decreased rate of disease flare, lower organ damage accrual, and better quality of life in Korean patients with SLE.Disclosure of InterestNone declared