AB0621 Expression of Serum B Cell Activating Factor from the Tumor Necrosis Factor Family (BAFF) and of Proliferation-Inducing Ligand (APRIL) in Patients with Untreated Systemic Lupus Erythematosus
Abstract:BackgroundB lymphocyte stimulator signaling pathway by BAFF and its homologue APRIL has an important role in the selection, maturation and survival of B cells and plays a significant role in the pathogenesis of systemic lupus erythematosus (SLE).ObjectivesThe aim of this study is to determine serum levels of BAFF and APRIL in patients with untreated SLE, excluding the influence of the therapy.MethodsThe study included 27 pts (81% females, age 30.0 [26.0-33.0] years (median [interquartile range 25%>75%]) with u… Show more
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