AB0727 Bone Mineral Density Depending on the Activity of Ankylosing Spondylitis in Men

Abstract

Background infringement of a metabolism of bone tissue caused by inflammation, increases the risk of developing osteoporosis (OP) and can be considered as an indicator of “seriousness” of the disease and the activity of inflammation. Objectives assess bone mineral density in men with ankylosing spondylitis (AS) depending on x-ray stage of the disease. Methods Under the supervision were 70 male patients with a diagnosis of as. The average age of patients 43,2±9.1 years. Patients were included in the study in a different time period from the onset of the speakers: 4.3 per cent in the first year of illness, 21,4% - while ago as 1 - 4 years, with the duration of 5-9 years - 25,7% and 48.6% of patients have 10 years or more. Among the 70 patients of 62.8% had only axial defeat. In 60,0% of cases in the radiography of spine identified Sindesmofitis, of them in the lumbar spine of 52.3% of patients, breast - 45.2% and in the cervical - 35,7%. Sindesmofitis in two departments of a backbone identified the 35,7%, and in all departments, 15% of patients, till the formation of the symptoms of “bamboo sticks.” Results When comparing the densitometric parameters in the groups of patients depending on radiological stage statistically significant decreasing of densitometric parameters of the proximal femur as the progression of radiographic changes. So, in men with I-II x-ray stage AU IPC hip was 947,8±15,13 g/cm2, which corresponds to -2,16±0,12 standard deviations by Z-test, while in stage III-IV AC IPC - 880,9±26,83 g/cm2, which corresponds to -2,66±0,19 standard deviations on the Z-test (p=0,0136 and R?0,001). However, in the lumbar spine densitometric parameters IPC increase as the progression of radiological stage. IPC at I-II stage was 1007,33±27,76 g/cm2 and -1,08±0.15 standard deviations by Z-test compared with the IPC with stage III-IV AC 1179,81±31,94 g/cm2 and -0,20±0,17 standard deviations on the Z-test (p=0,0106 and p=0,0216). Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.4162