AB0785 Relationship between Metabolic Syndrome and Its Components with Bone Density in Menopause Women

Abstract

BackgroundPrevention of osteoporosis and bone fracture and the relationship between metabolic syndrome and bone density are controversial issues.ObjectivesThe present study aimed to investigate metabolic syndrome and its components and the association with bone mineral density in post menopausal women referring for bone mineral density (BMD) test.MethodsA total of 143 postmenopausal women with at least one year of menopause experience participated in this cross-sectional study. Demographic and anthropometric characteristics for all participants were collected. Biochemical parameters including fasting blood sugar, Cholesterol (HDL and LDL), triglyceride were also measured prior to BMD test. Afterwards, association between the components of metabolic syndrome and bone densitometry were analyzed using statistical methods.ResultsIn this study, 72% of participants did not have metabolic syndrome. Among them, 43.4% and 28.7% had osteoporosis and normal density, respectively. Of the remaining28% with metabolic syndrome 12.6% had osteoporosis and 15.4% had normal density. Among the metabolic syndrome components, waist circumference, HDL cholesterol, and waist to hip ratio were found to be significantly associated with bone mass (P<0.05). Osteoporotic women had lower waist circumference and waist to hip ratio and higher HDL than women without osteoporosis. In contrast, women with metabolic syndrome did not have significant differences with women without metabolic syndrome in terms of lumbar and femoral neck densitometry (P>0.05).ConclusionsResults from this study showed that metabolic syndrome and its components did not induce bone mass loss. Due to discrepancies of the studies in this area, it seems that more studies are needed so as to make it possible to take some preventive measures in large scale.ReferencesNayak B, Pinto Pereira L, Seemungal T, Davis G, Teelucksingh S, Jagessar A, et al. Relationship of fasting total homocysteine, high sensitivity C-reactive protein and features of the metabolic syndrome in Trinidadian subjects. Archives of physiology and biochemistry. 2013;119(1):22–6.Demirtas RN, Ozel CB, Arikan H, Calik-Kutukcu E, Saglam M, Vardar-Yagli N, et al. C-reactive protein: Its correlations with pulmonary function, physical capacity and anthropometric measurements in patients with metabolic syndrome. European Respiratory Journal. 2014;44(Suppl 58):P4326.AcknowledgementThe authors gratefully acknowledge the cooperation of the study participants. We thank the subject volunteers and subject involved in data collectionDisclosure of InterestNone declared