AB0913 To determine the association between plaque and non plaque psoriasis with their joint manifestation in psoriatic arthritis patient – a single centre experience in malaysia

Abstract

BackgroundPsoriatic arthritis (PsA) which is a member of the spondyloarthritides includes spinal and peripheral joint involvement. It affects women and men equally. The clinical patterns of PsA were classified into 5 groups according to Moll and Wright..1 Psoriasis is a common chronic inflammatory skin disease and chronic plaque psoriasis is the commonest form.ObjectivesTo study the relationship between plaque and non-plaque psoriasis with their joint manifestation and to describe the demographic characteristics of PsA patients.MethodsThis was a restrospective study. The electronic medical records of all PsA patients under rheumatology clinic Hospital Sultan Ismail followed up from 1/1/2009 to 31/12/2017 were reviewed. Data on demography, type of skin disease, joint manifestation, past medical history, fasting serum lipid and body mass index were obtained and analysed.ResultsWe identified 163 patients, 84 were male patients with male to female ratio of 1.06. The Malays (84/163) were the majority being affected, followed by the Chinese (46/163), Indians (30/163) and others (3/163). The patients were divided into plaque psoriasis (140/163) and non-plaque psoriasis (23/163). The commonest joint involvement in the study was peripheral joint involvement (121/163), axial involvement (22/163) and both axial and peripheral joint involvement (20/163). The peripheral joint involvement was categorised as polyarthritis (67/121), followed by oligoarthritis (47/121), distal interphalangeal arthritis (4/121) and arthritis mutilans (3/121). In the study, we divided the patients into plaque psoriasis [peripheral joint involvement (102/140); axial involvement (16/140); both (18/140)] and non-plaque psoriasis [peripheral joint involvement (15/23); axial involvement (6/23); both (2/23)] and analysed the results by using the SPSS logistic regression. It showed no significant association between type of skin psoriasis with its joint manifestation. (p>0.05).Amongst the 163 patients, 68/163 (42%) had hypertension, 50/163 (31%) had diabetes mellitus, 32/163 (20%) had hypercholesterolemia, 12/163 have ischaemic heart disease, 1 patient had congestive heart disease, 3 had breast cancer, 1 had hepatocellular carcinoma and 2 have chronic kidney disease and cerebral vascular disease respectively.The fasting serum lipid (FSL) was taken for 140 of them (23 patients no data available) and it was noted in 64/140 (without background history of hypercholesterolemia was noted to have FSL≥5.18 mmol/L). 37/64 have borderline high total cholesterol (5.18 mmol/L –<6.2 mmol/L) and 27/64 have high total cholesterol (≥6.2 mmol/L) according to ATP iii cholesterol classification..2 43% (61/142 patients) had body mass index in the overweight group, 29% (41/142 patients) in the obese group and 25% (36/142 patients) in normal group according to WHO classification.3 ConclusionsThere was no association between types of skin psoriasis with their joint manifestation. There was a significant number of patients who had deranged fasting serum lipid and majority of them...

Relationship of age, body mass index (BMI), physical activity, salt intake, and stress with high blood pressure among rural dwellers in Kudat, Sabah

“…This study shows that hypertension increased with increasing age in males, subjects with a family history of hypertension, BMI, non-smokers, and decreased education levels. 5 A study shows that chronic exposure to psychological stress could elevate blood pressure and develop hypertension. 6 Furthermore, in Sabah, Malaysia there was 26.8% of those aged 18 years old and above were hypertensive.…”