Ab1266 the Correlation Between Smoking and Disease Activity and Mri Inflammation in Early Axial Spondyloarthritis in an Egyptian Cohort

Abstract

Background:literature suggests that smoking is one of the crucial triggering factors of rheumatological diseases.(1) In axial Spondyloarthritis (axSpA), classified into radiographic SpA (AS) and non-radiographic SpA (nrSpA), smoking associated with disease activity and extra-articular manifestation. (2) The relationship between smoking and HLAB-27 as well as MRI inflammation in axSpA patients and the difference between nrSpA and AS regarding smoking have not been studied to date in details.Objectives: to investigate the influence of smoking on disease activity and MRI inflammation in axSpA patients (AS and nrSpA).Methods:sixty Egyptian patients (42 males and 18 females) with the mean age (31.33 ± 7.02), with early active axial spondyloarthritis (49 AS and 11 non-radiographic SpA) within two years disease duration, diagnosed based on ASAS classification criteria. All clinical indices (BASDI, BASFI, BASMI, ASDAS-CRP) were applied to all patients. HLA-B27 and the inflammatory markers (ESR, CRP) was done. MRI of sacroiliac joints was performed in a standard protocol using short tau inversion recovery and T1 sequences (slice thickness 3-4mm, both semi-coronal and semi-axial orientations), and scored by the Berlin method. Smoking use assessed by smoking pack-year index.Results:of all 60 patients, 38 smokers and 22 non-smokers. No significant difference regarding smoking packs index between nrSpA and AS. (p=0.822) There was a robust correlation between smoking packing index and the Berlin score of MRI in all axSpA patients (rs=0.631) (p=<0.001). Moreover, there was a significant correlation between smoking and C-reactive protein (rs=0.952) as well as HLA-B27. (rs=0.340) (p<0.001) Furthermore, a significant relationship between smoking and activity indices (BASDI (rs=0.961) and ASDAS-CRP (rs=0.938)). Otherwise, no significant correlation among smoking, BASMI, and BASFI as well as ESR.Table (1): Correlation between smoking pack index and different parameters Disease activity Smoking pack index Non radiographic SpA (n = 11) Radiographic SpA (n = 49) Total (n = 60) rs p rs p rs p BASDI 0.986* <0.001* 0.224<0.001* 0.204<0.001* ASDAS-CRP 0.981* <0.001* 0.969* <0.001* 0.938* <0.001* rs: Spearman coefficient*: Statistically significant at p ≤ 0.05Table (2): Correlation between smoking pack index and HLAB27, inflammatory marker (CRP) and Berlin score of MRISmoking pack index Non radiographic SPA (n = 11) Radiographic SPA (n = 49) Total (n = 60) rs P rs p rs p HLAB27 0.602* 0.049* 0.293* 0.041* 0.340* 0.008* Berlin score of MRI 0.687* 0.020* 0.742* <0.001* 0.631* <0.001* CRP 0.991* <0.001* 0.970* <0.001* 0.952* <0.001* rs: Spearman coefficient*: Statistically significant at p ≤ 0.05Conclusion:Smoking has no significant difference between AS and nrSpA. Smoking has a significant association with HLA-B27, the inflammatory lesions of MRI, and clinical indices (BASDI, ASDAS-CRP) as well as C reactive protein in AS and non-radiographic SpA patients while it has no association with the other clinical in...

Ab1265 evaluation of Adherence to Treatment in Patients of Rheumatic Diseases

“…(1) In axial Spondyloarthritis (axSpA), classified into radiographic SpA (AS) and non-radiographic SpA (nrSpA), smoking associated with disease activity and extra-articular manifestation. (2) The relationship between smoking and HLAB-27 as well as MRI inflammation in axSpA patients and the difference between nrSpA and AS regarding smoking have not been studied to date in details. Objectives: to investigate the influence of smoking on disease activity and MRI inflammation in axSpA patients (AS and nrSpA).…”