Ab1332 cost Effective Biomarker in Predicting Sle in Developing Countries – Neutrophil Lymphocyte Ratio (Nlr), Platelet Lymphocyte Ratio (Plr), MPV

Abstract

BackgroundSLE is a disease which is easily missed in regular clinical practice. In developing countries due to lack of investigation modalities and rheumatologist, early identification of the diseases process is delayed. By the time the patient reaches a higher medical care centre there is a significant time loss and advancement of the disease. NLR, PLR, RDW and MPV can be calculated from a complete blood count which will be available at any grass route heath centre.ObjectivesTo identify Cost effective biomarkers in predicting SLE in developing countries. Focussing on markers - Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), MPV.MethodsThis is a retrospective hospital based observational study conducted screening patients admitted from January 2016- November 2018 in with a diagnosis of SLE. We identified 150 patients with SLE and their NLR, PLR, and MPV data were collected and were correlated with equal control group without SLEResultsWe found that NLR, PLR, and MPV were highly significant with a p-value of 0.001 to be used as bio marker and also when further analysis was done using ROC curve with an area under curve of 76%, 81% and 78% respectively when compared with the control group.ConclusionWe conclude that NLR,PLR,and MPV is cost-effective bio marker which costs (< 1 Euro) in predicting SLE and also play a great in monitoring following up referring patient to higher centre for biopsy at a golden period which will aid in early management which will limit the mortality and morbidity associated with the diseaseReferences[1] Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, Hu Z, Ling Y, Yang Z, Zhong R Neutrophil, to Lymphocyte ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. ModRhematol.2016;26(3):372-6. doi: 10.3109/14397595.2015.1091136. Epub 2016 Mar 4.[2] Wu Y1, Chen Y1, Yang X2, Chen L1, Yang Y3 Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus.Int Immunopharmacol. 2016 Jul;36:94-99. doi: 10.1016/j.intimp.2016.04.006. Epub 2016 Apr 22.[3] Soliman WM1, Sherif NM1, Ghanima IM1, El-Badawy MA2. Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios in Systemic Lupus Erythematosus: Relation With Disease Activity and Lupus Nephritis. [4] Reumatol Clin. 2018 Aug 27. pii: S1699-258X(18)30167-0. doi: 10.1016/j.reuma.2018.07.008. [Epub ahead of print]Disclosure of InterestsNone declared