Ab1450 hip Involvement in Tunisian Children With Juvenile Idiopathic Arthritis

Abstract

BackgroundJuvenile idiopathic arthritis (JIA) is characterized by widely heterogeneous clinical course and outcomes. Hips are the most commonly affected joints in severe uncontrolled JIA.ObjectivesThe aim of our study was to determine the prevalence and associated factors of hip involvement in Tunisian JIA patients.MethodsA retrospective and observational monocentric study including children with JIA according to the ILAR was conducted in the Rheumatology department of Sousse, Tunisia. We compared the disease parameters between the two groups with and without coxitis.ResultsWe included 55 children (28 girls and 27 boys). The mean age was 13.6 years. The predominant subtypes of JIA were the seronegative polyarticular JIA (38.2%), and the seronegative oligoarticular form and juvenile spondyloarthritis (16.4% each). Biological inflammatory syndrome was found in 65.5% of cases. The mean ESR and CRP was 42.4 mm/h and 28.8 mg/l respectively. Hip involvement concerned 30.9% of the patients (n=17) and was bilateral in 64.7% of cases (n=11). Coxitis occurred on average 10 years after the JIA onset. The mean Lequesne index was 12. Hip radiographs were normal in 40% of cases. Magnetic resonance imaging was performed in 25% of cases and revealed synovitis in 70% of cases. Overall, 61.8% of patients had medical treatment combining non steroidal anti-inflammatory drugs and rehabilitation. Only two patients had local infiltration with Hexatrione. In 12.7% of cases (7 cases), a total hip replacement was necessary. Hip involvement was significantly associated with younger age at onset (p=0.02), polyarticular subtype of JIA (p=0.04) and with the presence of biological inflammatory syndrome (p=0.03). However, coxitis was not significantly associated with gender, the duration of JIA progression, extraarticular manifestations, structural damage or the different used treatments.ConclusionOur study showed that hip involvement is frequent among Tunisian patients with JIA. Coxitis was associated with the polyarticular subtype, with biological inflammatory syndrome and younger age at onset of JIA.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.