Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

Abstract

Antibiotics provide promising strategies for treating periodontitis, while their delivery and controllable release with desired oral retention remain challenging. Here, inspired by the unique suction-cup structures of abalones, a novel adhesive and photo-responsive microparticle (MP) delivery system is developed to treat periodontitis through microfluidic electrospray technology. Such MPs are generated by quickly ionic cross-linking of sodium alginate together with photo-curing of poly(ethylene glycol) diacrylate of the distorted microfluidic droplets during their high-speed dropping into calcium chloride solution. Attributing to their unique concave structures, the abalone-inspired MPs exhibit desired underwater adhesion ability and stability under running water. In addition, due to the loading of antibiotics minocycline hydrochloride and near-infrared (NIR)-responsive black phosphorus during their fabrication, the resultant MPs can not only eradicate bacteria directly, but also realize a controllable and effective drug release upon NIR irradiation. Based on these features, it is demonstrated from in vivo periodontitis that the abalone-inspired MPs are firmly adhesive and can controlled-release drugs on the tooth, and thus have outstanding antibacterial efficacy against Porphyromonas gingivalis. These results indicate the particular values of the abalone-inspired MPs for oral-related disease treatment.

Ultrasound‐trigged micro/nanorobots for biomedical applications

“…In addition to the widely employed AuNWs, which inherently have asymmetric structures, researchers have also been working on creating structured objects using advance technologies. [74][75][76][77][78][79] they fabricated a platinum (Pt) micromotor with artificial concave and convex structures through a sphere-template method (Figure 3A). 48 Interestingly, the Pt micromotor can be propelled with or without US excitation (Figure 3B).…”

Pollen‐Inspired Adhesive Multilobe Microparticles from Microfluidics for Intestinal Drug Delivery

“…[3][4][5] To increase and maintain local drug concentrations, efforts have been focused on the development of drug carriers with retentive capacity. [6][7][8][9][10][11] Among them, microparticles (MPs) with adjustable morphologies and functionalities have attracted tremendous attention in gastrointestinal drug administration. [11][12][13][14] Current studies have figured several methods to enhance the adhesive property of MPs, including the modulation of the MPs morphologies to increase the contact area, the addition of adhesive molecules like polydopamine, and so on.…”

“…[6][7][8][9][10][11] Among them, microparticles (MPs) with adjustable morphologies and functionalities have attracted tremendous attention in gastrointestinal drug administration. [11][12][13][14] Current studies have figured several methods to enhance the adhesive property of MPs, including the modulation of the MPs morphologies to increase the contact area, the addition of adhesive molecules like polydopamine, and so on. [6,7,11,14] Despite the achieved progresses, the adhesion and motion property of these MPs remain unsatisfied due to the unstable state of these adhesion molecules in the dynamic and moist physiological environment, such as the gastrointestinal tract.…”

“…[11][12][13][14] Current studies have figured several methods to enhance the adhesive property of MPs, including the modulation of the MPs morphologies to increase the contact area, the addition of adhesive molecules like polydopamine, and so on. [6,7,11,14] Despite the achieved progresses, the adhesion and motion property of these MPs remain unsatisfied due to the unstable state of these adhesion molecules in the dynamic and moist physiological environment, such as the gastrointestinal tract. Therefore, MPs with well-designed microstructures and physicochemical properties are highly desired in constructing adhesive gastrointestinal drug-delivery systems.…”

Microfluidic Electrospray of Multifunctional Discal Microparticles for Wound Healing

“…In this paper, we proposed a novel multifunctional wound microcarrier dressing based on microfluidics-derived discal microparticles (DMPs) for wound healing, as shown in Figure . Microfluidic technology is well-known as a maneuverable strategy to fabricate monodispersed microparticles for applying in diverse areas. − Especially, the combination of microfluidic electrospray with biomaterials has opened up novel avenues for fabricating microcarriers, most of which are spherical as wound dressing. , Although with many values, these general spherical microcarriers are easy to shift and fall off due to the small contact area, which greatly affects their stability on the wound surface . In contrast, the microparticles in discal morphology exhibit prominent advantages of higher surface/volume ratio, better deformability, and side stacking capability. − Thus, it is conceived that an effective approach for wound healing can be achieved by harnessing discal microparticles as a wound dressing.…”