Abbreviated (12-Hour) Versus Traditional (24-Hour) Postpartum Magnesium Sulfate Therapy in Severe Preeclampsia

Early magnesium discontinuation postpartum and eclampsia risk: a systematic review and meta-analysis

“…Results Eight trials met the inclusion criteria for this meta-analysis with a total of 2,183 participants (1,088 in early magnesium group versus 1,095 in 24-hour regimen) (Table 1). [9][10][11][12][13][14][15][16] Figure 1 shows the flow diagram (PRISMA template) of records reviewed. Table S1 has characteristics of excluded studies.…”

“…16 Contact was made with seven trials and the authors of four of the included trials provided additional study information on request. 12,13,15,16 A review of the statistical methods used by the included studies did not reveal any discrepancies (Table S3). Three studies had an overall low risk of bias for all key domains as assessed by the Cochrane Collaboration's tool (Figure 2).…”

“…Three studies had an overall low risk of bias for all key domains as assessed by the Cochrane Collaboration's tool (Figure 2). 13,15,16 Four studies had unclear or high risk of bias in allocation concealment and selective reporting. 9,11,12,14 None of the studies were double-blinded, thus all were judged to be at high risk of performance bias as assessed by the Cochrane Collaboration's tool.…”

“…Seven trials 9,[11][12][13][14][15] included only women with preeclampsia with severe features, and two trials of 1,397 patients included in this meta-analysis used the definition of preeclampsia with severe features by ACOG criteria. 14,15 There were five different time frames for early magnesium discontinuation (Table 1): 1).…”

“…Twelve hour postpartum regimen of magnesium, three studies. 10,12,13 Average maternal age at time of randomization was 25.8 versus 26.3 years. The majority of women were nulliparous; twin pregnancies (when reported) constituted a small proportion of studied women (0.7 -3.6%, 3 studies) (Table S5).…”