ABC of Atrial Fibrillation: HISTORY, EPIDEMIOLOGY, AND IMPORTANCE OF ATRIAL FIBRILLATION

Lip, G Y H; Beevers, D. G.

doi:10.1136/bmj.311.7016.1361

Cited by 130 publications

(81 citation statements)

References 4 publications

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“…7 Furthermore, it has been suggested that AF may be the sole manifestation of CAD. 8 However, most data supporting this association have been derived from studies using the presence of ECG abnormalities and a history of ischemic heart disease to define CAD 4,9,10 rather than direct visualization of atherosclerosis.…”

Section: Clinical Perspective See P 106mentioning

confidence: 99%

Prevalence of Coronary Artery Disease Assessed by Multislice Computed Tomography Coronary Angiography in Patients With Paroxysmal or Persistent Atrial Fibrillation

Nucifora

Schuijf

Tops

et al. 2009

Circ: Cardiovascular Imaging

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Background-Although atrial fibrillation (AF) has been linked to underlying coronary artery disease (CAD), data supporting this association have been based on ECG and clinical history for the definition of CAD rather than direct visualization of atherosclerosis. Methods and Results-The prevalence of CAD among patients with paroxysmal or persistent AF and without history of CAD was evaluated using multislice computed tomography. Multislice computed tomography was performed in 150 patients with AF (61Ϯ11 years, 67% males, 58% asymptomatic) with predominantly low (59%) or intermediate (25%) pretest likelihood of CAD. CAD was classified as obstructive (Ն50% luminal narrowing) or not. A population of 148 patients without history of AF, similar to the AF group as to age, gender, symptomatic status, and pretest likelihood, served as a control group. Logistic regression analysis was applied to evaluate the relationship between demographic and clinical data and the presence of obstructive CAD. On the basis of multislice computed tomography, 18% of patients with AF were classified as having no CAD, whereas 41% showed nonobstructive CAD and the remaining 41% had obstructive CAD. Among patients without AF, 32% were classified as having no CAD, whereas 41% showed nonobstructive CAD and 27% had obstructive CAD (Pϭ0.010 compared with patients with AF). At logistic regression analysis, age, male gender, and the presence of AF were significantly related to obstructive CAD. Conclusion-A higher prevalence of obstructive CAD was observed among patients with AF, confirming the hypothesis that AF could be a marker of advanced coronary atherosclerosis. (Circ Cardiovasc Imaging. 2009;2:100-106.)

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Section: Clinical Perspective See P 106mentioning

confidence: 99%

Prevalence of Coronary Artery Disease Assessed by Multislice Computed Tomography Coronary Angiography in Patients With Paroxysmal or Persistent Atrial Fibrillation

Nucifora

Schuijf

Tops

et al. 2009

Circ: Cardiovascular Imaging

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“…Bien que probablement reconnue pour la première fois il y a environ 4000 ans par un médecin chinois (Huang Ti Nei Ching Su Wen), et décrite en Occident par le père de la circulation sanguine, l'éminent William Harvey en 1628 [3], ce n'est qu'à partir du début du XX ème siècle que les premières hypothèses physiopathologiques concernant la FA furent élaborées. A cette époque, trois théories principales s'affrontaient, qui demeurent encore d'actualité à ce jour: la FA était due à une hyperactivité ectopique avec un ou plusieurs foyers auriculaires rapides, un circuit de réen-trée unique avec une conduction fibrillatoire («onde mère») ou à des circuits de réentrées multiples simultanés ( fig.…”

Section: Aspects Historiquesunclassified

Mécanismes physiopathologiques de la fibrillation auriculaire

2008

Schweiz Ärzteztg

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SummaryThe pathophysiology of atrial fibrillation is complex, and appears to result from the interaction between initiating triggers, often in the form of rapidly firing ectopic foci located in the pulmonary veins, and an abnormal atrial tissue substrate capable of maintaining the arrhythmia through mechanisms such as multiple wavelet reentry or multiple rotors. Moreover, atrial remodelling, autonomic tone variations and inflammation also may be involved in the genesis and maintenance of atrial fibrillation. Ultimately, the recent understanding of some of these mechanisms has led to new therapeutic strategies, such as radiofrequency catheter and surgical ablation techniques. At the present time, a strategy of radiofrequency catheter ablation tailored to the burden of atrial fibrillation allows efficient management of patients, with a high rate of long-term freedom from recurrence of atrial fibrillation.

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“…Puede decirse que la FA es la arritmia crónica más frecuente en la población, que es poco común en menores de 50 años y que la prevalencia aumenta con la edad 1 . A partir de varios estudios de base poblacional se estima la prevalencia de la FA en Estados Unidos en un 2,3% en menores de 40 años, del 5,6% en mayores de 65 años y sobrepasa el 10% en mayores de 80 años.…”

Section: Introductionunclassified

“…A pesar de lo descrito, la FA ha sido vista frecuentemente como una patología de poca importancia y es, a menudo, desatendida, probablemente porque en muchos pacientes es poco sintomática. De hecho hasta los años ochenta se consideraba el tratamiento antitrombótico sólo en los casos de FA asociados a valvulopatía reumática 1,9 . Pretendemos con este trabajo conocer el tratamiento antitrombótico de los pacientes con FA en el ámbito de la Atención Primaria, valorando la adecuación del tratamiento a las directrices actuales.…”

Section: Introductionunclassified

Tratamiento antitrombótico en pacientes con fibrilación auricular: estudio descriptivo en Atención Primaria

Ramírez¹,

López²,

Gallego³

et al. 2003

Medifam

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ABC of Atrial Fibrillation: HISTORY, EPIDEMIOLOGY, AND IMPORTANCE OF ATRIAL FIBRILLATION

Cited by 130 publications

References 4 publications

Prevalence of Coronary Artery Disease Assessed by Multislice Computed Tomography Coronary Angiography in Patients With Paroxysmal or Persistent Atrial Fibrillation

Prevalence of Coronary Artery Disease Assessed by Multislice Computed Tomography Coronary Angiography in Patients With Paroxysmal or Persistent Atrial Fibrillation

Mécanismes physiopathologiques de la fibrillation auriculaire

Tratamiento antitrombótico en pacientes con fibrilación auricular: estudio descriptivo en Atención Primaria

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