ABC of blood pressure reduction. Drug treatment.

Bannan, L T; Beevers, D. G.; Wright, Nate

doi:10.1136/bmj.281.6246.982

Cited by 10 publications

(4 citation statements)

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“…A discount of ceruloplasmin in the plasma is a sign of WD [23]. Although copper starts to accumulate in the liver from first few year of life onwards [31,32]. The only sign being fatty liver and hypertransaminasemia, a symptomatic and revolutionary liver disorder appears later [19].…”

Section: Wilson's Disordermentioning

confidence: 99%

“…That's not just due to genetics. Family individuals generally tend to proportion comparable eating and activity habits [32].…”

Section: Family Life-stylementioning

confidence: 99%

“…When we reduce the use of sugar and starch it made the person less hungry and results in less consumption of calories [19]. Instead of using fats for energy [32]. Body starts feeding off-stored fats [36], the insulin level also lowers that helped kidneys to remove high quantity of sodium and water out of the body [23].…”

Section: Cut Back On Sugar and Starchmentioning

confidence: 99%

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How Obesity Affects Our Health

Iqbal¹,

Ullah²,

Masood³

et al. 2019

Natl. j. health sci.

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Introduction: Obesity is a form in which there is fat collection of body overweight or adipose tissue. This accumulation happens in lean body mass of muscles and unlike connective tissue. Obesity is consummate constantly defined by the body mass index (BMI), a mathematically formula of weight-for-height index. BMI has a high interaction with adiposity and it interacts well with fat weight at the population rank. Obesity is defined as abnormal all excessive accumulation that may be harmful to health. Although, its etiology has been associated with and energy imbalance between calories consumed and calories expended, which is mainly as a result of a poor diet and insufficient physical exercise. Obesity is a worldwide epidemiologic syndrome depict by fat mass accumulation, mainly visceral fat. Obesity cause several diseases like genetic and metabolic issues, urea cycle problems, turner syndrome, Down syndrome, cystic fibrosis and Wilson's disease etc. Several factors are the cause of obesity like high sugar consumption but by taking some precautionary measures we can be secure from obesity.

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Section: Wilson's Disordermentioning

confidence: 99%

“…That's not just due to genetics. Family individuals generally tend to proportion comparable eating and activity habits [32].…”

Section: Family Life-stylementioning

confidence: 99%

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How Obesity Affects Our Health

Iqbal¹,

Ullah²,

Masood³

et al. 2019

Natl. j. health sci.

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“…The results of the Hypertension Detection and Follow‐up Programme 4,5 have led to the recommendation that the therapy of hypertensive patients should be increased in stages to obtain a diastolic blood pressure of 90mm Hg or below 6 . If the blood pressure of hypertensive patients is not controlled on a beta blocker or diuretic alone as monotherapy it has been recommended that therapy should be altered to a combination of both 7 . To determine the efficacy and suitability of such an approach to the treatment of hypertension this is a study of the progress of patients who entered three trials, 8 designed to evaluate a combination tablet of timolol 10mg, hydrochlorothiazide 25mg and amiloride 2.5mg (THA) in the treatment of hypertension.…”

Section: Introductionmentioning

confidence: 99%

The Use of A Single Combination Tablet Containing A Beta Blocker and A Diuretic in Patients Uncontrolled on Either Alone

Vandenburg

Currie

Cooper

1984

Int J Clinical Practice

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Treatment of essential hypertension and hypertension associated with renal impairment with pinacidil: A new vasodilator

Breen

Mulhall

Keogh

1985

Eur J Clin Pharmacol

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Twenty patients with uncontrolled hypertension were treated with pinacidil for a mean period of 43 weeks (range 10-63 weeks). All patients achieved and maintained significant reductions in blood pressure. The supine blood pressure at baseline was 184/116 mmHg; after one week it was 161/95 mmHg and at 43 weeks it was 138/79 mmHg. The mean dose of pinacidil was 30 mg/day. There was no significant difference between the two groups with respect to the dose of pinacidil or the blood pressure response. Pulse rate and weight remained stable for the group as a whole. Five patients were not taking beta-blockers. The mean baseline pulse rate for this group was 78 beats/min and when maintained on pinacidil it was 82 beat/min (NS). Six patients were not taking diuretics. The mean baseline weight for this group was 78.5 kg and while maintained on pinacidil it was 79.2 kg (NS). There was no occurrence of oedema, hirsutism or first dose phenomenon. The mean glomerular filtration rate and renal plasma flow for the renal plasma flow for the renal group was 35.4 ml/min and 192.3 ml/min before pinacidil and after six months they were 32.7 ml/min and 183.2 ml/min (NS) respectively. Six patients experienced minor side-effects. We conclude that pinacidil is a potent, well tolerated antihypertensive agent which merits further study.

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ABC of blood pressure reduction. Drug treatment.

Cited by 10 publications

References 0 publications

How Obesity Affects Our Health

How Obesity Affects Our Health

The Use of A Single Combination Tablet Containing A Beta Blocker and A Diuretic in Patients Uncontrolled on Either Alone

Treatment of essential hypertension and hypertension associated with renal impairment with pinacidil: A new vasodilator

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