ABC OF Work Related Disorders: OCCUPATIONAL CANCERS

Veys, C. A.

doi:10.1136/bmj.313.7057.615

Cited by 11 publications

(3 citation statements)

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“…Moreover, the increase in haemolymphopoietic cancer or leukaemia mortality occurred earlier than that of liver cancer. Although factors affecting the induction period of carcinogenesis include age, genetic susceptibility, exposure dose and general health conditions, cancers of epithelial origin usually take longer to develop than cancers of non-epithelial origin 43 44. Our results are consistent with these observations.…”

Section: Discussionsupporting

confidence: 91%

Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: an updated study

et al. 2010

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Section: Discussionsupporting

confidence: 91%

Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: an updated study

et al. 2010

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“…The presence of four much less common upper urothelial tract tumours plotted on the map in the at-risk group heralds a likely occupational hazard [19]. Additional pointers that assisted interpretation were that the risk was essentially confined to theoretically exposed groups and that there was a shift to younger ages at onset [19].…”

Section: Discussionmentioning

confidence: 96%

Bladder tumours in rubber workers: a factory study 1946-1995

Veys

2004

Occupational Medicine

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“…The main agents held responsible are aromatic amines (naphthylamine and benzidine) and polycyclic aromatic hydrocarbons. The tumors may sometimes appear 15-40 years after initial exposure [29].…”

Section: Somatic Dna Carcinogenesis and Genetic Pathwaysmentioning

confidence: 99%

Anatomical Location of Urothelial Carcinomas of the Urinary Tract Leads To Perspectives of Specific Treatment

Rouprêt

2007

Future Oncol.

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'The ultimate goal is to relate the tumor genotype with the individual's phenotype and to offer patients treatment that is adapted to the specific molecular pattern of their cancer.'The urothelium is the epithelium that lines the upper and lower urinary tract. Over 95% of urothelial carcinomas are derived from the urothelium [1,2]. They can be located in the lower tract (bladder or urethra) or upper tract (pyelocaliceal cavities or ureter). Urothelial carcinomas are the fourth most common tumors after prostate (or breast) cancer, lung cancer and colorectal cancer. Bladder tumors account for 90-95% of urothelial carcinomas, and it is the most common malignancy of the urinary tract and the second most common malignancy of the urogenital tract after prostate cancer. It accounts for 5-10% of all cancers diagnosed each year in Europe [1,2]. Bladder cancer is ranked the 11th most common cancer in the world and over 50% of cases occur in developed countries [1,2]. Conversely, upper urinary tract transitional cell carcinomas (UUT-TCCs) are scarce and account for only 5-10% of urothelial carcinomas [2,3]. The estimated annual incidence in Western countries is approximately one to two new cases per 100,000 inhabitants.'Bladder cancer is ranked the 11th most common cancer in the world and over 50% of cases occur in developed countries.'Pyelocaliceal tumors are approximately twice as common as ureteral tumors. In 8-13% of cases, a synchronous bladder cancer is present. Recurrence in the bladder or the contralateral urinary tract occurs in 30-51% of UUTTCCs. The natural history of UUT-TCCs differs from that of bladder cancer: 60% of UUTTCCs are invasive at diagnosis compared with only 15% of bladder tumors. Moreover, UUTTCCs invading the muscle wall usually have a very poor prognosis. The 5-year specific survival is less than 50% for pT2/pT3 and less than 10% for pT4 [3,4]. Although the mechanisms of carcinogenesis are thought to be similar throughout the urinary tract, recent epidemiological data and genetic studies suggest otherwise. It is now obvious that strong differences exist with regard to tumor location and behavior between the upper and the lower urinary tract.

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ABC OF Work Related Disorders: OCCUPATIONAL CANCERS

Abstract: Pott, a British surgeon who described scrotal cancer in boy chimney sweeps. A century later, in 1895, Rehn, a German surgeon working in Frankfurt, treated a cluster of three cases of bladder cancer in workers at a local factory

Cited by 11 publications

References 1 publication

Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: an updated study

Mortality from liver cancer and leukaemia among polyvinyl chloride workers in Taiwan: an updated study

Bladder tumours in rubber workers: a factory study 1946-1995

Anatomical Location of Urothelial Carcinomas of the Urinary Tract Leads To Perspectives of Specific Treatment

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