ABC transporter-mediated MXR mechanism in fish embryos and its potential role in the efflux of nanoparticles

Yin, Jian; Hu, Jia; Deng, Xudong; Zheng, Yu; Tian, Jingjing

doi:10.1016/j.ecoenv.2023.115397

Cited by 4 publications

(1 citation statement)

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“… 49 , 50 The two are responsible for supplying chemical energy to the human ABC transporter proteins are divided into seven subfamilies, named ABCA through ABCG in sequence, and are mainly distributed in organs with secretory and excretory functions, protecting the body from external toxins and drugs. 51 , 52 At least 12 transporter proteins of the ABC transporter family have been shown to be associated with tumor cell drug resistance, facilitation of drug catabolism by tumor cells. Accelerated catabolism of drugs by tumor cells results in lower drug concentrations in tumor cells and reduced drug killing efficacy.…”

Section: Advances In Chemotherapy For Gliomamentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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