ABCC11 gene polymorphism as a potential predictive biomarker for an oral 5-fluorouracil derivative drug S-1 treatment in non-small cell lung cancer

Uemura, Takashi; Oguri, Tetsuya; Maeno, Ken; Sone, Kazuki; Takeuchi, Akihiro; Fukuda, Satoshi; Kunii, Eiji; Takakuwa, Osamu; Kanemitsu, Yoshihiro; Ohkubo, Hirotsugu; Takemura, Masashi; Ito, Yutaka

doi:10.1007/s00280-019-03959-3

Cited by 6 publications

(1 citation statement)

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“…They can extrude various exogenous and endogenous compounds in an ATP-dependent manner from the cell. Several studies DOI: 10.33808/clinexphealthsci.757619 ABCC5 and ABCC11 Gene Variations in 5-FU Pharmacokinetics Original Article have shown that 5-FU and its active metabolite, 5-FdUMP, are potential substrates for ABCC5 and ABCC11 (12,13). Genetic alterations in genes encoding ABC transporters are an important pharmacokinetic-based source for differences in response to antineoplastic drugs including 5-FU.…”

Section: Introductionmentioning

confidence: 99%

The association of ABCC5 and ABCC11 polymorphisms with the pharmacokinetics of 5-FU in advanced gastric cancer patients

Kara

Öztaş

Öztürk

et al. 2020

Clinical and Experimental Health Sciences

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Objective: Gastric cancer is the second leading cause of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used drugs to treat cancer, but 5-FU and its forms are characterized by wide inter-individual pharmacokinetic variability. ABCC5 and ABCC11 are members of the ABC transporter superfamily and play a role in the efflux of antineoplastic drugs like 5-FU. Methods: The influence of two SNPs in ABCC5 (rs562, T>C) and ABCC11 (rs17822931, G>A) was evaluated based on the pharmacokinetics and toxicity of 5-FU in HER2-negative advanced gastric cancer patients treated with cisplatin and 5-FU (n=18). The genetic variants and plasma 5-FU concentrations were detected by RT-PCR and HPLC, respectively. Results: There was no statistically significant difference between 5-FU AUC 0-96 h values and ABCC5 (rs562; T>C), 21.04 ±3.46 vs 16.65 μg.h/mL, p=0.261 and ABCC11 (rs17822931; G>A), 17.04 ±4.39 vs 54 ±3.79 μg.h/mL, p=0.564 variants. Similarly, there were no statistically significant differences between the variants and the most frequently observed side effects of diarrhea and mucositis. Conclusion: We recommend investigating the noted SNPs more precisely in a larger study population with more comprehensive evaluation.

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Section: Introductionmentioning

confidence: 99%