Abdominal adiposity and liver fat content 3 and 12 months after gastric banding surgery

Heath, Madeleine L.; Kow, Lilian; Slavotinek, John; Valentine, Robin; Toouli, Jim; Thompson, Campbell

doi:10.1016/j.metabol.2008.05.021

Cited by 33 publications

(25 citation statements)

References 34 publications

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“…RYGB induced an impressive weight loss at 29% (mean 36 ± 11 kg) and the weight loss was accompanied by a significant reduction in the level of sCD163 (2.1 ± 0.8 mg/l vs. 1.7 ± 0.7 mg/l, P < 0.001) which is in line with previous studies showing a reduction in sCD163 in relation to diet‐induced weight loss . Furthermore, the weight loss was accompanied by a significant reduction in the total fat mass, SAT, VAT, and IHL (all, P < 0.001) with a preferential reduction of IHL and VAT compared with SAT (both, P < 0.05) which has been described previously . Massive weight loss in relation with RYGB is associated with improvement of the metabolic profile and likewise, we found a reduction in the circulating inflammatory cytokines IL‐6 and hs‐CRP, decreased level of HOMA‐IR, diabetes remission, and increased level of adiponectin after RYGB.…”

Section: Discussionsupporting

confidence: 89%

Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux‐en‐Y gastric bypass

Fjeldborg

Pedersen

Møller

et al. 2014

Obesity

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Objective: Soluble CD163 (sCD163) is a new marker of obesity-related metabolic complications. sCD163 and CD163 mRNA were investigated in relation to the fat distribution at baseline and 12 months after Roux-en-Y gastric bypass (RYGB). Methods: Thirty-one obese subjects (BMI: 42.3 6 4.7 kg/m 2 ) were enrolled. Subcutaneous (SAT) and visceral adipose tissue (VAT) volume were determined by MRI, intrahepatic lipid content (IHL) by MRspectroscopy, and body composition by DXA. Fasting blood samples and adipose tissue samples were obtained, and ELISA and RT-PCR were performed. Results: RYGB-induced weight loss (36 6 11 kg) was accompanied by a significant reduction in sCD163 (2.1 6 0.8 mg/l vs. 1.7 6 0.7 mg/l), SAT, VAT, and IHL (all, P < 0.001). At baseline, sCD163 was associated with VAT (r 5 0.40, P < 0.05) but not with SAT or IHL. Moreover, CD163 mRNA was significantly upregulated in VAT compared with SAT at baseline (P < 0.05) and significantly downregulated in SAT after RYGB (P < 0.001). DsCD163 was significantly associated with DIHL after RYGB compared with baseline (r 5 0.40, P < 0.05). Conclusions: RYGB-induced weight loss results in a reduction of sCD163 and CD163 mRNA. The association between DsCD163 and DIHL may reflect a reduction in sCD163-producing Kupffer cells in the liver. Moreover, sCD163 may be a marker of "unhealthy" fat distribution in obese subjects.

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Section: Discussionsupporting

confidence: 89%

Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux‐en‐Y gastric bypass

Fjeldborg

Pedersen

Møller

et al. 2014

Obesity

View full text Add to dashboard Cite

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“…Similar results were observed by Hearth and colleagues in a population of 18 female obese subjects who underwent laparoscopic adjustable gastric banding surgery: they used magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to quantify abdominal subcutaneous and visceral adipose tissue areas and liver fat content before and 3 and 12 months after surgery [73].…”

Section: Weight Loss Visceral Fat and Ectopic Fat Depositionsupporting

confidence: 73%

Visceral Fat Predicts Ectopic Fat Accumulation Mechanisms and Health Consequences

Rossi

Fantin

Bertassello

et al. 2014

Nutrition in the Prevention and Treatment of Abdominal Obesity

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“…As fat mass is a stronger predictor of leptin levels compared to body weight, it is possible that a minimal reduction in body fat mass after GB is responsible for the lack of change in leptin levels. However, many studies have reported a significant reduction in fat mass one year after GB (41-43), suggesting that leptin levels would also decrease after this surgery. It will be interesting to see if these differential effects persist in a larger group when all subjects are at weight maintenance.…”

Section: Discussionmentioning

confidence: 99%

Superior Appetite Hormone Profile After Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding

Bose

Machineni

Oliván

et al. 2010

Obesity

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The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight‐ and age‐matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY3–36 (PYY3–36), ghrelin, glucagon‐like peptide‐1 (GLP‐1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose‐stimulated GLP‐1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP‐1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP‐1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.

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Abdominal adiposity and liver fat content 3 and 12 months after gastric banding surgery

Cited by 33 publications

References 34 publications

Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux‐en‐Y gastric bypass

Intrahepatic fat content correlates with soluble CD163 in relation to weight loss induced by Roux‐en‐Y gastric bypass

Visceral Fat Predicts Ectopic Fat Accumulation Mechanisms and Health Consequences

Superior Appetite Hormone Profile After Equivalent Weight Loss by Gastric Bypass Compared to Gastric Banding

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