Abdominal Aortic Aneurysm in Normotensive Patients: Association with Angiotensin-converting Enzyme Gene Polymorphism

Pola, Roberto; Gaetani, Eleonora; Santoliquido, Angelo; Gerardino, Laura; Cattani, Paola; Serricchio, Michele; Tondi, Paolo; Flore, Roberto; Grande, Michele; Carbonin, P. U.; Fadda, Guido; Pola, Paolo

doi:10.1053/ejvs.2001.1339

Cited by 49 publications

(45 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,12 The potential for slowing AAA disease progression with medication targeting the RAS has already been suggested by a large therapeutic study. 9 Further functional work is now needed to better understand the pathophysiology behind these findings.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II Type 1 Receptor 1166C Polymorphism Is Associated With Abdominal Aortic Aneurysm in Three Independent Cohorts

Jones

Thompson

Bockxmeer

et al. 2008

ATVB

View full text Add to dashboard Cite

Objectives-Although polymorphic variations in genes of the RAS system have previously been associated with susceptibility to AAA, such studies have been significantly limited by small sample sizes. This study was undertaken, using the largest case series yet reported, to determine whether common genetic variants of the RAS are associated with either susceptibility or severity of AAA. Methods and Results-The frequencies of 4 common genetic variants of genes related to the renin-angiotensin system were investigated in 3 geographically distinct, but ethnically similar, case-control cohorts, resulting in comparison of 1226 AAA cases with 1723 controls. In all 3 the AGTR1 1166C allele was significantly more common in AAA patients than controls (overall adjusted OR 1. Key Words: abdominal aortic aneurysm Ⅲ angiotensinogen Ⅲ angiotensin converting enzyme Ⅲ angiotensin Ⅲ Bradykinin Ⅲ genetic association Ⅲ renin T he renin-angiotensin system (RAS) is a potent mediator of cardiovascular homeostasis. The principal effector, angiotensin II (Ang II), is most widely associated with its role in the regulation of arterial blood pressure, but has been implicated in a wide range of nonpressor related actions including vascular remodeling, fibrosis, endothelial dysfunction, oxidative stress, 1,2 and dyslipidemia. 3 Reduction of Ang II levels, by inhibition of its converting enzyme (ACE), has been shown to significantly reduce cardiovascular disease morbidity and mortality. 4 Abdominal aortic aneurysm (AAA) is a common condition, being present in approximately 4% of white men between the ages of 50 to 79 years. 5 The condition is associated with a distinct familial component, with up to 20% of patients having one or more first affected relatives. 6 Evidence of a link between the RAS and abdominal aortic degeneration has been shown in experimental animal models, with exogenous Ang II inducing abdominal aortic aneurysms in the apolipoprotein E-deficient mouse, 7 and RAS blockade reducing spontaneous aortic elastic tissue degeneration in the rat, independent of changes in blood pressure. 8 In humans, ACE inhibitors have been suggested to reduce AAA rupture, an effect not observed with other antihypertensive agents. 9 Genetic polymorphisms of the RAS have been implicated as potential susceptibility candidates in a variety of vascular disorders including coronary artery disease, myocardial infarction, and hypertension. The role of the RAS related polymorphisms has been previously investigated in AAA patients. 10 -13 Fatini and coworkers, in the largest and most recent of these studies, investigated 250 cases and reported a significant association between ACE deletion homozygotes and AAA susceptibility. 10 All of the studies to date have involved small patient cohorts without adequate independent replication.Recently, a combinational effect of ACE, AGT, and AGTR1 SNPs has been reported for susceptibility to diabetic nephrop-

show abstract

Section: Discussionmentioning

confidence: 99%

Angiotensin II Type 1 Receptor 1166C Polymorphism Is Associated With Abdominal Aortic Aneurysm in Three Independent Cohorts

Jones

Thompson

Bockxmeer

et al. 2008

ATVB

View full text Add to dashboard Cite

show abstract

“…Such link has on the other hand been identified by others. [3][4][5] Previous experimental studies lend support to the suggestion that ACE has a role in aneurysm formation. 28,29 Accumulation of ACE has been reported in the abdominal aortic wall in patients with aneurysm, 28 and angiotensin II infusion induces AAA in mice.…”

Section: Multiple Regression Analysesmentioning

confidence: 75%

“…1,2 In addition, this polymorphism has been associated with abdominal aortic aneurysm (AAA), [3][4][5] although this association has been questioned. 6 The abdominal aorta is of particular interest as age-and gender-related changes are more pronounced at this site than other arteries 7 and as the abdominal aorta is particularly prone to aneurysm formation.…”

Section: Introductionmentioning

confidence: 99%

P4.04 Impaired Abdominal Aortic Wall Integrity in Elderly Men Carrying the Angiotensin-Converting Enzyme D-Allele

Ljungberg

Basso

Alehagen

et al. 2010

ARTRES

View full text Add to dashboard Cite

show abstract

“…More recently, an association with AAA has been demonstrated by several studies who have found a significantly increased D allele frequency in AAA patients compared to controls (Fatini et al, 2005a). Furthermore, it has been shown that this polymorphism affects AAA development independently of any association with blood pressure (Pola et al, 2001). Interestingly, aldosterone does not mediate angiotensin induced increases in AAA diameter.…”

Section: Because the Alleles Are Co-dominant With An A D D I T I V E mentioning

confidence: 99%

Pathophysiology of Abdominal Aortic Aneurysm – Genetic Factors and Homocysteine Metabolism

Delaney¹,

Saleem²,

Wong³

et al. 2011

Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

View full text Add to dashboard Cite

Abdominal Aortic Aneurysm in Normotensive Patients: Association with Angiotensin-converting Enzyme Gene Polymorphism

Abstract: our data suggest a role for ACE I/D gene polymorphism in the pathogenesis of AAA in normotensive patients.

Cited by 49 publications

References 29 publications

Angiotensin II Type 1 Receptor 1166C Polymorphism Is Associated With Abdominal Aortic Aneurysm in Three Independent Cohorts

Angiotensin II Type 1 Receptor 1166C Polymorphism Is Associated With Abdominal Aortic Aneurysm in Three Independent Cohorts

P4.04 Impaired Abdominal Aortic Wall Integrity in Elderly Men Carrying the Angiotensin-Converting Enzyme D-Allele

Pathophysiology of Abdominal Aortic Aneurysm – Genetic Factors and Homocysteine Metabolism

Contact Info

Product

Resources

About